Chordin-like 1/CHRDL1 Protein, Human (His, solution)
The CHRDL1 protein acts as a BMP4 antagonist, blocking its receptor interaction and redirecting neural stem cells from gliogenesis to neurogenesis. The role of CHRDL1 in preventing glial cell fate adoption supports neuronal differentiation in the brain. Chordin-like 1/CHRDL1 Protein, Human (His, solution) is the recombinant human-derived Chordin-like 1/CHRDL1 protein, expressed by E. coli , with N-His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The CHRDL1 protein acts as a BMP4 antagonist, blocking its receptor interaction and redirecting neural stem cells from gliogenesis to neurogenesis. The role of CHRDL1 in preventing glial cell fate adoption supports neuronal differentiation in the brain. Chordin-like 1/CHRDL1 Protein, Human (His, solution) is the recombinant human-derived Chordin-like 1/CHRDL1 protein, expressed by E. coli , with N-His labeled tag.
Background
The Chordin-like 1 (CHRDL1) protein serves as an antagonist to BMP4 by binding to it, thus impeding its interaction with receptors. This interaction leads to a shift in the fate commitment of neural stem cells, steering them away from gliogenesis towards neurogenesis. CHRDL1's involvement in preventing the adoption of a glial fate contributes to the neuronal differentiation of neural stem cells in the brain. Beyond its role in neural development, CHRDL1 may play a crucial part in dorsoventral axis formation and embryonic bone development (By similarity). Additionally, CHRDL1 is implicated in regulating retinal angiogenesis by modulating BMP4 actions in endothelial cells. Its participation in anterior segment eye development underscores its multifaceted role in various developmental processes.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-His
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Accession
Q9BU40-1 (E28-C456)
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Molecular Construction
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N-term
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His
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CHRDL1 (E28-C456)
Accession # Q9BU40-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
CHRDL1; Neuralin-1; Prev. MGC1; Megalocornea 1 (X-Linked); NRLN1; DA141H5.1; CHL; MGCN; Chordin-Like Protein 1; VOPT; Neurogenesin-1; Chordin Like 1; Ventroptin
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AA Sequence
EQVKHSETYCMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQAGGLSRFPGARSHRGALMDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKELPGQSFDNKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQWKIFTEGEAQISQMCSSRVCRTELEDLVKVLYLERSEKGHC
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Predicted Molecular Mass
50 kDa
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Molecular Weight
Approximately 50 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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