CHRDL1 - chordin like 1 Gene

Homo sapiens

Also known as CHL; MGC1; MGCN; VOPT; NRLN1; dA141H5.1

Gene ID: 91851 | Gene type: protein coding

About CHRDL1

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:110,673,856-110,795,817 (from NCBI)

This gene has 5 transcripts (splice variants), 122 orthologues, 19 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 100.2), prostate (RPKM 57.9) and 15 other tissues.

Summary

This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

CHRDL1 Products(10)

mRNA	Protein	Name
NM_001143981.2	NP_001137453.1	chordin-like protein 1 isoform 1 precursor
NM_001143982.2	NP_001137454.1	chordin-like protein 1 isoform 2 precursor
NM_001143983.3	NP_001137455.2	chordin-like protein 1 isoform 4 precursor
NM_001367204.1	NP_001354133.1	chordin-like protein 1 isoform 1 precursor
NM_001367205.1	NP_001354134.1	chordin-like protein 1 isoform 5 precursor
NM_001367206.1	NP_001354135.1	chordin-like protein 1 isoform 5 precursor
NM_001367207.1	NP_001354136.1	chordin-like protein 1 isoform 6 precursor
NM_001367208.1	NP_001354137.1	chordin-like protein 1 isoform 7 precursor
NM_001367209.1	NP_001354138.1	chordin-like protein 1 isoform 8 precursor
NM_145234.4	NP_660277.2	chordin-like protein 1 isoform 3 precursor

CHRDL1 Protein Structure

VWC

0
100
200
300
400
450 a.a.

Protein Preferred Names

Protein Names

chordin-like protein 1

neuralin-1

Recombinant CHRDL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77896	Chordin-like 1/CHRDL1 Protein, Human (His, solution)	Q9BU40 (E28-C456)	≥95%

Related Diseases

Diseases

Alias

Megalocornea

Isolated Congenital Megalocornea	Congenital Anterior Megalophthalmia
Anterior Megalophthalmos	Mgc1
Mgcn	Congenital Keratoglobus

Combined Oxidative Phosphorylation Deficiency 11

COXPD11	Combined Oxidative Phosphorylation Defect Type 11
Infantile Encephaloneuromyopathy Due To Mitochondrial Translation Defect	Encephaloneuromyopathy, Infantile, Due To Mitochondrial Translation Defect
Combined Oxidative Phosphorylation Deficiency, Type 11

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Fuchs' Heterochromic Uveitis

Fuchs' Heterochromic Cyclitis	Fuchs Heterochromic Iridocyclitis
Fhi	Fuchs Heterochromic Cyclitis
Fuch'S Heterochromic Iridocyclitis	Fuchs Uveitis Syndrome
Fuchs Heterochromic Uveitis

Amme Complex

Alport Syndrome, Mental Retardation, Midface Hypoplasia, And Elliptocytosis	ATS-MR
Alport Syndrome-Intellectual Disability-Midface Hypoplasia-Elliptocytosis Syndrome	Chromosome Xq22.3 Telomeric Deletion Syndrome
Amme Syndrome	Alport Syndrome With Intellectual Disability, Midface Hypoplasia And Elliptocytosis

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02657	CHRDL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CHRDL1	RGD	RGD:735215
Felis catus	CHRDL1	VGNC	VGNC:60871
Canis familiaris	CHRDL1	VGNC	VGNC:39229
Bos taurus	CHRDL1	VGNC	VGNC:84868
Mus musculus	CHRDL1	MGD	MGI:1933172
Macaca mulatta	CHRDL1	VGNC	VGNC:71139
Others	CHRDL1	NCBI

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