CHRDL1 - chordin like 1 Gene

Also Known as CHL; MGC1; MGCN; VOPT; NRLN1; dA141H5.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91851

About CHRDL1

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:110,673,856-110,795,817 (from NCBI)

This gene has 5 transcripts (splice variants), 122 orthologues, 19 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 100.2), prostate (RPKM 57.9) and 15 other tissues.

Summary

This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

CHRDL1 Products (10)

mRNA Protein Name
NM_001143981.2 NP_001137453.1 chordin-like protein 1 isoform 1 precursor
NM_001143982.2 NP_001137454.1 chordin-like protein 1 isoform 2 precursor
NM_001143983.3 NP_001137455.2 chordin-like protein 1 isoform 4 precursor
NM_001367204.1 NP_001354133.1 chordin-like protein 1 isoform 1 precursor
NM_001367205.1 NP_001354134.1 chordin-like protein 1 isoform 5 precursor
NM_001367206.1 NP_001354135.1 chordin-like protein 1 isoform 5 precursor
NM_001367207.1 NP_001354136.1 chordin-like protein 1 isoform 6 precursor
NM_001367208.1 NP_001354137.1 chordin-like protein 1 isoform 7 precursor
NM_001367209.1 NP_001354138.1 chordin-like protein 1 isoform 8 precursor
NM_145234.4 NP_660277.2 chordin-like protein 1 isoform 3 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in eye development IMP
IMP: Inferred from mutant phenotype
22284829 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHRDL1 Protein Structure

VWC

VWC: von Willebrand factor type C domain (31 - 93)

VWC

VWC: von Willebrand factor type C domain (109 - 172)

VWC

VWC: von Willebrand factor type C domain (254 - 316)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 450 a.a.
Protein Preferred Names Protein Names

chordin-like protein 1

  • neuralin-1

Recombinant CHRDL1 Proteins

Cat. No. Product Name Accession Purity
HY-P77896 Chordin-like 1/CHRDL1 Protein, Human (His, solution) Q9BU40-1 (E28-C456) ≥ 95%, as determined by Bis-Tris PAGE.

CHRDL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85422 CHRDL1 Antibody (YA5114) WB Human, Rat
HY-P85541 CHRDL1 Antibody (YA5233) WB, IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Megalocornea

  • Isolated Congenital Megalocornea

  • Congenital Anterior Megalophthalmia

  • Anterior Megalophthalmos

  • Mgc1

  • Mgcn

  • Congenital Keratoglobus
Combined Oxidative Phosphorylation Deficiency 11

  • COXPD11

  • Combined Oxidative Phosphorylation Defect Type 11

  • Infantile Encephaloneuromyopathy Due To Mitochondrial Translation Defect

  • Encephaloneuromyopathy, Infantile, Due To Mitochondrial Translation Defect

  • Combined Oxidative Phosphorylation Deficiency, Type 11
Lymphoma, Hodgkin, Classic

  • Hodgkin Lymphoma

  • Hodgkin Disease

  • Hodgkin'S Lymphoma

  • Hodgkins Lymphoma

  • Classic Hodgkin Lymphoma

  • CHL

  • Hodgkin Lymphoma, Susceptibility To

  • Hl

  • Hodgkin'S Sarcoma

  • Stage I Subdiaphragmatic Hodgkin Lymphoma

  • Stage Ii Subdiaphragmatic Hodgkin Lymphoma

  • Lymphoma, Hodgkin'S

  • Classic Hodgkin Disease

  • Hodgkin'S Disease

  • Lymphoma, Hodgkin, Susceptibility To

  • Hodgkin'S Disease Of Intrapelvic Lymph Nodes

  • Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

  • Malignant Lymphogranuloma

  • Malignant Lymphogranulomatosis

  • Malignant Hodgkin Lymphoma

  • Classical Hodgkin Lymphoma, Type Not Specified
Fuchs' Heterochromic Uveitis

  • Fuchs' Heterochromic Cyclitis

  • Fuchs Heterochromic Iridocyclitis

  • Fhi

  • Fuchs Heterochromic Cyclitis

  • Fuch'S Heterochromic Iridocyclitis

  • Fuchs Uveitis Syndrome

  • Fuchs Heterochromic Uveitis
Amme Complex

  • Alport Syndrome, Mental Retardation, Midface Hypoplasia, And Elliptocytosis

  • ATS-MR

  • Alport Syndrome-Intellectual Disability-Midface Hypoplasia-Elliptocytosis Syndrome

  • Chromosome Xq22.3 Telomeric Deletion Syndrome

  • Amme Syndrome

  • Alport Syndrome With Intellectual Disability, Midface Hypoplasia And Elliptocytosis
Cataract

  • Cataracts

  • Cat - [Cataract]

  • Cataract Form

  • Lens Opacity

  • Lens Opacities
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02657 CHRDL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18418 Chrdl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24899 Chrdl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992218 Anti-CHRDL-1 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CHRDL1 RGD RGD:735215
Felis catus CHRDL1 VGNC VGNC:60871
Canis familiaris CHRDL1 VGNC VGNC:39229
Bos taurus CHRDL1 VGNC VGNC:84868
Mus musculus CHRDL1 MGD MGI:1933172
Macaca mulatta CHRDL1 VGNC VGNC:71139
Others CHRDL1 NCBI