CHRDL1 Antibody (YA5233)

Cat. No.: HY-P85541: Data Sheet User Guide for Antibodies
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CHRDL1 Antibody (YA5233) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CHRDL1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

CHRDL1 Antibody (YA5233) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CHRDL1.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Observed band size: 52 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9BU40

Gene ID

91851 [NCBI]

Immunogen

Purified recombinant human CHRDL1 protein fragments expressed in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:300
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:300

Purity	affinity chromatography.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development

Subcellular Localization：Secreted

Expression：
Tissue_specificity:In addition to the retina, this gene is also expressed in the developing cornea and anterior segment of the eye. It shows differential expression in the fetal brain. It is highly expressed in the cerebellum and neocortex. It is expressed in the pericytes of the retina.

Induction:By hypoxia in retinal pericytes

Isoforms & Post-Translational Modification：Q9BU40 has 4 isomers: Q9BU40-6: 52026 Da (predicted); Q9BU40-3: 43516 Da (predicted); Q9BU40-4: 52284 Da (predicted); Q9BU40-5: 52155 Da (predicted).

Synonyms

CHL; chordin like 1; Chordin-like protein 1; CHRDL1; CRDL1_HUMAN; dA141H5.1; neuralin 1; Neuralin-1; Neurogenesin-1; NRLN1; Ventroptin; VOPT.

Documentation

User Guide for Antibodies (1077 KB)