CHRDL1 Antibody (YA5233)
(Synonyms: CHL; chordin like 1; Chordin-like protein 1; CHRDL1; CRDL1_HUMAN; dA141H5.1; neuralin 1; Neuralin-1; Neurogenesin-1; NRLN1; Ventroptin; VOPT.)CHRDL1 Antibody (YA5233) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CHRDL1.
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Host:
Mouse
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:300 | 1:300 |
Product Details
CHRDL1 Antibody (YA5233) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CHRDL1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Purified recombinant human CHRDL1 protein fragments expressed in E.coli.
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CHRDL1 is an Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development
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Subcellular Localization
Secreted
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Expression
Tissue_specificity:In addition to the retina, this gene is also expressed in the developing cornea and anterior segment of the eye. It shows differential expression in the fetal brain. It is highly expressed in the cerebellum and neocortex. It is expressed in the pericytes of the retina.
Induction:By hypoxia in retinal pericytes -
Isoforms & Post-Translational Modification
Q9BU40 has 4 isomers: Q9BU40-6: 52026 Da (predicted); Q9BU40-3: 43516 Da (predicted); Q9BU40-4: 52284 Da (predicted); Q9BU40-5: 52155 Da (predicted).
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SwissProt ID
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Synonyms
CHL; chordin like 1; Chordin-like protein 1; CHRDL1; CRDL1_HUMAN; dA141H5.1; neuralin 1; Neuralin-1; Neurogenesin-1; NRLN1; Ventroptin; VOPT.
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