B7H4 Antibody (YA9689)
(Synonyms: B7 family member, H4, B7 H4, B7 homolog 4, B7 superfamily member 1, B7 superfamily, member 1, B7-H4, B7h.5, B7h4, B7S1, B7x)B7H4 Antibody (YA9689) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to B7H4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000 | 1:1000 |
Product Details
B7H4 Antibody (YA9689) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to B7H4.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 31 kDa;
Synthetic peptide of human B7H4 (aa 101-150).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
B7-H4 (also known as B7-S1, B7x and VCTN1), a member of the CD28/B7 family, is a transmembrane protein and a T-cell immune co-inhibitory molecule. B7-H4 negatively regulates T cell immune response and promotes immune escape by inhibiting the proliferation
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC) . Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level) . Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis
Induction:Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells (APCs) -
Isoforms & Post-Translational Modification
Q7Z7D3 has 4 isomers: Q7Z7D3-1: 30878 Da (predicted); Q7Z7D3-2: 18275 Da (predicted); Q7Z7D3-3: 9875 Da (predicted); Q7Z7D3-4: 20743 Da (predicted).
N-glycosylated -
SwissProt ID
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Synonyms
B7 family member, H4, B7 H4, B7 homolog 4, B7 superfamily member 1, B7 superfamily, member 1, B7-H4, B7h.5, B7h4, B7S1, B7x
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