1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Alniditan dihydrochloride

Alniditan dihydrochloride (Synonyms: Alnitidan dihydrochloride)

Cat. No.: HY-101698B
Handling Instructions

Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK 293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects.

For research use only. We do not sell to patients.

Alniditan dihydrochloride Chemical Structure

Alniditan dihydrochloride Chemical Structure

CAS No. : 155428-00-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 385 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Alniditan dihydrochloride:

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Description

Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK 293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects[1][2].

IC50 & Target[2]

human 5-HT1B Receptor

1.7 nM (IC50)

human 5-HT1D Receptor

1.3 nM (IC50)

5-HT1B Receptor

0.9 nM (Kd)

5-HT1D Receptor

1.2 nM (Kd)

In Vitro

In vitro, Alniditan exhibits little vasoconstrictive effects on the rat basilar artery, although at a very high concentration 1 mM, Alniditan causes intensive constriction, most likely through a mechanism independent from 5-HT receptor activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The intraperitoneal administration of Alniditan ED50=9 μg/kg dose dependly reduces [125I]-BSA extravasation in the rat meninges when done 30 min before stimulation. Alniditan dose dependently attenuateds the neurogenic inflammation in vivo model of neurogenic inflammation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

375.34

Formula

C₁₇H₂₈Cl₂N₄O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (166.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6643 mL 13.3213 mL 26.6425 mL
5 mM 0.5329 mL 2.6643 mL 5.3285 mL
10 mM 0.2664 mL 1.3321 mL 2.6643 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.54 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Alniditan dihydrochloride
Cat. No.:
HY-101698B
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