Alniditan dihydrochloride (Synonyms: Alnitidan dihydrochloride)

Name: Alniditan dihydrochloride
Brand: MedChemExpress
SKU: HY-101698B
Rating: 4.5 (1 reviews)

Cat. No.: HY-101698B Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Alniditan (Alnitidan) dihydrochloride is a potent 5-HT_1B and 5-HT_1D receptors agonist, with IC₅₀s of 1.7 nM and 1.3 nM for h5-HT_1B and h5-HT_1D receptors in HEK 293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects.

For research use only. We do not sell to patients.

Alniditan dihydrochloride Chemical Structure

CAS No. : 155428-00-5

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 385	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 385	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Alniditan dihydrochloride:

Alniditan Get quote

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View All Isoforms

5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[2]

human 5-HT_1B Receptor

1.7 nM (IC₅₀)

human 5-HT_1D Receptor

1.3 nM (IC₅₀)

5-HT_1B Receptor

0.9 nM (Kd)

5-HT_1D Receptor

1.2 nM (Kd)

In Vitro

In vitro, Alniditan exhibits little vasoconstrictive effects on the rat basilar artery, although at a very high concentration 1 mM, Alniditan causes intensive constriction, most likely through a mechanism independent from 5-HT receptor activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The intraperitoneal administration of Alniditan ED₅₀=9 μg/kg dose dependly reduces [¹²⁵I]-BSA extravasation in the rat meninges when done 30 min before stimulation. Alniditan dose dependently attenuateds the neurogenic inflammation in vivo model of neurogenic inflammation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

375.34

Formula

C₁₇H₂₈Cl₂N₄O

CAS No.

155428-00-5

Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.[H]Cl.C1(NCCCNC[C@H]2CCC3=CC=CC=C3O2)=NCCCN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (166.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6643 mL	13.3213 mL	26.6425 mL
5 mM	0.5329 mL	2.6643 mL	5.3285 mL
10 mM	0.2664 mL	1.3321 mL	2.6643 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Limmroth V, et al. Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery. Eur J Pharmacol. 1999 Oct 8;382(2):103-9. [Content Brief]

[2]. Lesage AS, et al. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123(8):1655-65. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6643 mL	13.3213 mL	26.6425 mL	66.6063 mL
	5 mM	0.5329 mL	2.6643 mL	5.3285 mL	13.3213 mL
	10 mM	0.2664 mL	1.3321 mL	2.6643 mL	6.6606 mL
	15 mM	0.1776 mL	0.8881 mL	1.7762 mL	4.4404 mL
	20 mM	0.1332 mL	0.6661 mL	1.3321 mL	3.3303 mL
	25 mM	0.1066 mL	0.5329 mL	1.0657 mL	2.6643 mL
	30 mM	0.0888 mL	0.4440 mL	0.8881 mL	2.2202 mL
	40 mM	0.0666 mL	0.3330 mL	0.6661 mL	1.6652 mL
	50 mM	0.0533 mL	0.2664 mL	0.5329 mL	1.3321 mL
	60 mM	0.0444 mL	0.2220 mL	0.4440 mL	1.1101 mL
	80 mM	0.0333 mL	0.1665 mL	0.3330 mL	0.8326 mL
	100 mM	0.0266 mL	0.1332 mL	0.2664 mL	0.6661 mL

Alniditan dihydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alniditan155428-00-5Alnitidan5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1B5-HT1DmigrainepreventiveInhibitorinhibitorinhibit

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Alniditan dihydrochloride (Synonyms: Alnitidan dihydrochloride)

Customer Review

Other Forms of Alniditan dihydrochloride:

Alniditan dihydrochloride Related Antibodies

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•Related Small Molecules:

•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Alniditan dihydrochloride Related Antibodies

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Complete Stock Solution Preparation Table

Alniditan dihydrochloride Related Classifications

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