1. Neuronal Signaling
  2. Serotonin Transporter
  3. Indalpine

Indalpine (Synonyms: LM 5008)

Cat. No.: HY-A0160
Handling Instructions

Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM. Indalpine, two antidepressant agent.

For research use only. We do not sell to patients.

Indalpine Chemical Structure

Indalpine Chemical Structure

CAS No. : 63758-79-2

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Description

Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM[1]. Indalpine, two antidepressant agent[2].

In Vivo

In keeping with its potent reuptake-blocking property, acute IV Indalpine produces a marked decrease in the firing rate of dorsal raphe 5-HT neurons (ED50 0.33 mg/kg). The firing rate of dorsal raphe 5-HT neurons is assessed following 2-, 7- and 14-day treatments with Indalpine (5 mg/day IP). After 2 days, the firing rate of 5-HT neurons is greatly reduced, after 7 days it has recovered partially and after 14 days it has returned to normal[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

228.33

Formula

C15H20N2

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Indalpine
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