Melitracen
Melitracen (Melitracene) is an orally active tricyclic antidepressant and it is also a bipolar thymoleptic with activating properties. Melitracen inhibits 3H-5-HT and 14H-5-HT with IC50s of 670 nM and 5500 nM, respectively. Melitracen can be used for the research of depression and anxiety.
At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Melitracen hydrochloride) usually boasts enhanced water solubility and stability.
For research use only. We do not sell to patients.
- CAS No.: 5118-29-6
- Formula: C21H25N
- Molecular Weight:291.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Other In-stock Forms of Melitracen
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
Description
IC50 & Target
IC50: 670 nM (3H-5-HT), 5500 nM (14H-5-HT)[2]
In Vitro
Melitracen (0-10 μM; 10 min) inhibits 3H-5-HT in synaptosomes and 14H-5-HT in blood platelets[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Synaptosomes and blood platelets from male albino rats
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Concentration:0-10 μM
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Incubation Time:10 min
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Result:Inhibited 3H-5-HT in synaptosomes and 14H-5-HT in blood platelets with IC50s of 670 nM and 5500 nM, respectively.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female Wistar rats[1]
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Dosage:10, 30 and 90 mg/kg
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Administration:Oral gavage; 10-90 mg/kg daily; for 3 months
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Result:Showed aggressive behaviour, excitability, body and livers weight gain, and livers slight atrophic with increasing dose to rats.
Chemical Information
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CAS No. 5118-29-6
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Molecular Weight 291.43
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Formula C21H25N
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SMILES
CN(CC/C=C1C2=C(C(C)(C3=CC=CC=C\13)C)C=CC=C2)C
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Synonyms
Melitracene; N 7001; Trausabun
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Shimamoto K, et al. Relationship between the restriction of food intake and Melitracen, an antidepressant, in the rat. Acta Sch Med Univ Kioto. 1967 Jul;40(1):25-37. [Content Brief]
[2]. Hyttel J. Effect of a specific 5-HT uptake inhibitor, citalopram (Lu 10-171), on 3H-5-HT uptake in rat brain synaptosomes in vitro. Psychopharmacology (Berl). 1978 Dec 15;60(1):13-8. doi: 10.1007/BF00429172. PMID: 104340. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Melitracen Related Classifications
HY-121778 Related Classifications
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