1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Melitracen hydrochloride

Melitracen hydrochloride 

Cat. No.: HY-108256 Purity: 99.48%
Handling Instructions

Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space.

For research use only. We do not sell to patients.

Melitracen hydrochloride Chemical Structure

Melitracen hydrochloride Chemical Structure

CAS No. : 10563-70-9

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 110 In-stock
Estimated Time of Arrival: December 31
100 mg USD 145 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Melitracen hydrochloride:

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  • Biological Activity

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Description

Melitracen hydrochloride is an orally active biphasic antidepressant and antianxiety agent. Melitracen hydrochloride can inhibit the uptake of Norepinephrine and 5-HT (serotonin) through the presynaptic membrane inducing the increase of monoamine transmitters in synaptic space[1][2].

IC50 & Target

5-HT receptor[1]

In Vivo

Single oral administration of either Imipramine or Melitracen produces a marked and long lasting mydriasis in mice. The mydriatic effect of Melitracen is more marked and longer lasting. Melitracen is more effective with respect to behavioral excitement. Single oral administration of Melitracen produces lowering of the catechol amine levels in the brain stem, the cerebral cortex, the spleen, and the adrenals[2].
No significant changes in catecholamine levels of the brain stem, the cerebral cortex, and the spleen were observed in rats receiving daily doses of Melitracen for 13 and 15 weeks. The adrenalin level in the adrenals, however, is slightly decreased[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

327.89

Formula

C21H26ClN

CAS No.
SMILES

CN(C)CC/C=C1C2=C(C=CC=C2)C(C)(C)C3=CC=CC=C/13.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (304.98 mM; Need ultrasonic)

DMSO : 100 mg/mL (304.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0498 mL 15.2490 mL 30.4980 mL
5 mM 0.6100 mL 3.0498 mL 6.0996 mL
10 mM 0.3050 mL 1.5249 mL 3.0498 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.62 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.48%

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Product Name:
Melitracen hydrochloride
Cat. No.:
HY-108256
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