2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Lerimazoline

Lerimazoline is a selective 5-HT1D receptor agonist with Ki values of 72 and 3480 nM for h5-HT1D and h5-HT1B. Lerimazoline inhibits Forskolin (HY-15371)-stimulated cAMP production and induces contractions in rabbit saphenous vein preparations. Lerimazoline can be used for the research of migraine.

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Lerimazoline

Lerimazoline Chemical Structure

CAS No. : 54765-26-3

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Lerimazoline Related Antibodies

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Description

Lerimazoline is a selective 5-HT1D receptor agonist with Ki values of 72 and 3480 nM for h5-HT1D and h5-HT1B. Lerimazoline inhibits Forskolin (HY-15371)-stimulated cAMP production and induces contractions in rabbit saphenous vein preparations. Lerimazoline can be used for the research of migraine[1].

IC50 & Target[1]

5-HT1D Receptor

72 nM (Ki)

5-HT1B Receptor

3480 nM (Ki)

In Vitro

Lerimazoline (Compound 29) (0.1-1 μM; 60 min) binds to human h5-HT1B receptors with a Ki of 3480 nM[1].
Lerimazoline (0.1-1 μM; 60 min) binds to human h5-HT1D receptors with a Ki of 72 nM, displaying 48-fold selectivity for h5-HT1D over h5-HT1B receptors[1].
Lerimazoline (1-10 μM; 30 min) inhibits Forskolin (HY-15371)-stimulated cAMP production in transfected CHO Pro 5 cells[1].
Lerimazoline (10-10000 nM) induces contractions of rabbit saphenous vein with a 95% of the maximal effect[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lerimazoline Related Antibodies
Molecular Weight

202.30

Formula

C13H18N2
CAS No.
SMILES

CC1=C(CC2=NCCN2)C(C)=CC(C)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Lerimazoline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lerimazoline54765-26-35-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorh5-HT1B receptorsh5-HT1D receptors5-HT receptorrabbit saphenous vein preparationstransfected cellsCHO Pro 5 cellsadenylate cyclasemigrainecAMPforskolinInhibitorinhibitorinhibit

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