Neuraminidase-IN-11
Neuraminidase-IN-11 (15e) is a potent and selective neuraminidase (NA) inhibitor with the IC50 values of 4.7 nM, 8.46 nM and 1.5 nM against H1N1, H5N1 and H5N8 NAs respectively.
For research use only. We do not sell to patients.
- CAS No.: 2685786-28-9
- Formula: C26H34N2O5S
- Molecular Weight:486.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Fibroblast | CC50 |
>250 μM
Compound: 15e
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Cytotoxicity against chick embryo fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
Cytotoxicity against chick embryo fibroblast cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
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[PMID: 35939763] |
| MDCK | CC50 |
>250 μM
Compound: 15e
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Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 35939763] |
Neuraminidase-IN-11 (15e) (0-6 μM, 40 min)has anti-NA (Neuraminidase) activity against H1N1-H274Y mutant and H5N1-H274Y mutant with the IC50 values of 1.07 μM and 0.61 μM, respectively[1].
Neuraminidase-IN-11 (15e) (0-20 μM, 48 h) inhibits chicken embryo fibroblasts (CEFs) infected H5N1 or H5N8 with the IC50 values of 4.4 μM and 0.57 μM respectively, and inhibits Madin−Darby canine kidney (MDCK) cells infected H1N1 or H3N2 with the IC50 values of 0.05 μM and 12.65 μM respectively[1].
Neuraminidase-IN-11 (15e) has no significant inhibitory effect on the major CYP enzymes which acts on CYP1A2, CYP2C9 and CYP2C19 with the IC50 values of 28.9 μM, 47.3 μM and 47.8 μM, respectively[1].
The metabolic stability parameters of Neuraminidase-IN-11 (15e) in human liver microsomes (HLM)[1].
| Parameters | Neuraminidase-IN-11 (15e) |
| t1/2 (min) | >145 |
| CLint(mic) (μL/min/kg) | <9.6 |
| CLint(liver) (mL/min/kg) | <8.6 |
| remaining (T = 60 min) (%) | 79.3 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague−Dawley rat[1]
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Dosage:
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Administration:2 mg/kg, i.v.; 20 mg/kg, p.o.
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Result:The pharmacokinetic parameters of Neuraminidase-IN-11 (15e)
Parameters 15e (i.v.) 15e (p.o.) t1/2 (h) 0.213 0.863 Tmax (h) 0.083 0.5 Cmax (ng/mL) 7195 491 Vdss (mL/kg) 179 - CL 17.2 - F (%) - 1.58
Chemical Information
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CAS No. 2685786-28-9
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Molecular Weight 486.62
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Formula C26H34N2O5S
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SMILES
O=C(C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](NCC2=CC=C(C3=CSC=C3)C=C2OC)C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neuraminidase-IN-11 Related Classifications
HY-151104 Related Classifications
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