Influenza A virus-IN-8
Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC50s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a Kd of 1.0 nM.
For research use only. We do not sell to patients.
- Formula: C104H142N28O24S
- Molecular Weight:2200.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Influenza A virus-IN-8 (5 μM; 72 h) does not affect viability of HeLa and MDCKI cells[1].
Influenza A virus-IN-8 (5 μM; 24 h) shows neutralizing effect on H1N1pdm09 and H5N1 in a dose-dependent manner[1].
Influenza A virus-IN-8 (5 nM; 2 h) binds to a conserved region in the HA stem with Kd of 1.0 nM for H1 variants[1].
Influenza A virus-IN-8 (5 μM; 1 h) inhibits HA fusion activity during entry by stabilizing the prefusion conformation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa and MDCKI cells
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Concentration:5 μM
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Incubation Time:72 h
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Result:Exhibited no detectable cytotoxicity in HeLa and MDCKI cells.
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Cell Line:MDCK-II cells (ATCC; H1N1pdm09 and H5N1 infection)
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Concentration:5 µM
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Incubation Time:24 h
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Result:Againsted H1N1pdm09 and H5N1 in MDCK-II cells in a dose-dependent manner.
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Cell Line:MDCKI cells (transfected the pFRT expression plasmids encoding the full-length H1)
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Concentration:5 nM
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Incubation Time:2 h
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Result:Decreased the staining of full length, membrane-bound H1 HA expressed on the surface of MDCK cells, and binded to a conserved region in the HA stem with Kd of 1.0 nM.
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Cell Line:MDCKI cells
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Concentration:5 µM
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Incubation Time:1 h
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Result:Exhibited aeffect on surpressing HA fusion activity during entry by stabilizing the prefusion conformation in MDCKI cells.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Molecular Weight 2200.48
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Formula C104H142N28O24S
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Synonyms
S5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Influenza A virus-IN-8 Related Classifications
HY-149034 Related Classifications
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