2. Anti-infection
  3. Influenza Virus
  4. Influenza A virus-IN-8

Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC50s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a Kd of 1.0 nM.

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Influenza A virus-IN-8 Chemical Structure

Influenza A virus-IN-8 Chemical Structure

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Influenza A virus-IN-8 Related Antibodies

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Description

Influenza A virus-IN-8 (S5) is a macrocyclic peptide with no cytotoxic. Influenza A virus-IN-8 is also a potent Influenza A Virus (IAV) inhibitor (with sufficient protease stability) with IC50s of 6.7 and 6.6 nM for H1 and H5 variants, respectively. Influenza A virus-IN-8 shows good affinitiescan to H1 variants, binds to a conserved region in the HA stem with a Kd of 1.0 nM[1].

In Vitro

Influenza A virus-IN-8 (5 μM; 72 h) does not affect viability of HeLa and MDCKI cells[1].
Influenza A virus-IN-8 (5 μM; 24 h) shows neutralizing effect on H1N1pdm09 and H5N1 in a dose-dependent manner[1].
Influenza A virus-IN-8 (5 nM; 2 h) binds to a conserved region in the HA stem with Kd of 1.0 nM for H1 variants[1].
Influenza A virus-IN-8 (5 μM; 1 h) inhibits HA fusion activity during entry by stabilizing the prefusion conformation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Influenza A virus-IN-8 Related Antibodies

Cell Viability Assay[1]

Cell Line: HeLa and MDCKI cells
Concentration: 5 μM
Incubation Time: 72 h
Result: Exhibited no detectable cytotoxicity in HeLa and MDCKI cells.

Cell Viability Assay[1]

Cell Line: MDCK-II cells (ATCC; H1N1pdm09 and H5N1 infection)
Concentration: 5 µM
Incubation Time: 24 h
Result: Againsted H1N1pdm09 and H5N1 in MDCK-II cells in a dose-dependent manner.

Cell Viability Assay[1]

Cell Line: MDCKI cells (transfected the pFRT expression plasmids encoding the full-length H1)
Concentration: 5 nM
Incubation Time: 2 h
Result: Decreased the staining of full length, membrane-bound H1 HA expressed on the surface of MDCK cells, and binded to a conserved region in the HA stem with Kd of 1.0 nM.

Cell Viability Assay[1]

Cell Line: MDCKI cells
Concentration: 5 µM
Incubation Time: 1 h
Result: Exhibited aeffect on surpressing HA fusion activity during entry by stabilizing the prefusion conformation in MDCKI cells.
Clinical Trial
Molecular Weight

2200.48

Formula

C104H142N28O24S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Influenza A virus-IN-8 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Influenza A virus-IN-8S5S 5S-5Influenza VirusvaccineHAinfluenza A virusesH1H5IAVHeLaMDCKIMDCK-IIInhibitorinhibitorinhibit

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