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Referencia número: HY-163522

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Neuraminidase-IN-20

Neuraminidase-IN-20 (Compound 5i) is a potent inhibitor of mutant neuraminidase (NA) (H5N1-H274Y) (IC₅₀= 0.44 μM).Neuraminidase-IN-20 binds to the 430 cavity site of NA and disrupts the enzymatic activity of NA.

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No. CAS: 3040120-35-9
Fòrmula: C₂₁H₁₈FN₃O₂S
Peso molecular:395.45

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Neuraminidase-IN-20 Chemical Structure

No. CAS: 3040120-35-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	55.29 μM Compound: 5i	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 38608962]

In Vitro

Neuraminidase-IN-20 (45-66 μM; 72 h) shows cytotoxicity in A549 cells^[1].
Neuraminidase-IN-20 forms multiple hydrogen bonds with several key residues in NA (e.g: Arg118 and Arg371), which significantly increases the inhibitory effect on NA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A549 cells
Concentration:

45-66 μM
Incubation Time:

72h
Result:

Had cytotoxic at higher concentrations (CC₅₀ = 55.29 μM).

Chemical Information

No. CAS 3040120-35-9
Peso molecular 395.45
Fòrmula C₂₁H₁₈FN₃O₂S
SMILES

C/C(C1=CC=C(C=C1)NC(CC2=CC=CS2)=O)=N\NC(C3=CC=C(C=C3)F)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Fu SK, et al.Discovery andsynthesis of novel benzoylhydrazone neuraminidase inhibitors. Bioorg Med Chem Lett. 2024 Jun 1;105:129743. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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