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Cat. No.: HY-163522

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Neuraminidase-IN-20

Neuraminidase-IN-20 (Compound 5i) is a potent inhibitor of mutant neuraminidase (NA) (H5N1-H274Y) (IC₅₀= 0.44 μM).Neuraminidase-IN-20 binds to the 430 cavity site of NA and disrupts the enzymatic activity of NA.

For research use only. We do not sell to patients.

CAS No.: 3040120-35-9
Formula: C₂₁H₁₈FN₃O₂S
Molecular Weight:395.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Neuraminidase-IN-20 Chemical Structure

CAS No.: 3040120-35-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	55.29 μM Compound: 5i	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 38608962]

In Vitro

Neuraminidase-IN-20 (45-66 μM; 72 h) shows cytotoxicity in A549 cells^[1].
Neuraminidase-IN-20 forms multiple hydrogen bonds with several key residues in NA (e.g: Arg118 and Arg371), which significantly increases the inhibitory effect on NA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A549 cells
Concentration:

45-66 μM
Incubation Time:

72h
Result:

Had cytotoxic at higher concentrations (CC₅₀ = 55.29 μM).

Chemical Information

CAS No. 3040120-35-9
Molecular Weight 395.45
Formula C₂₁H₁₈FN₃O₂S
SMILES

C/C(C1=CC=C(C=C1)NC(CC2=CC=CS2)=O)=N\NC(C3=CC=C(C=C3)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fu SK, et al.Discovery andsynthesis of novel benzoylhydrazone neuraminidase inhibitors. Bioorg Med Chem Lett. 2024 Jun 1;105:129743. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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