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(E)-Capsaicin-d3

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0007
    (E,E)-Bisdemethoxycurcumin
    3 Publications Verification

    (E,E)-Curcumin III; (E,E)-Didemethoxycurcumin

    Apoptosis Autophagy Cancer
    (E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities.
    (<em>E</em>,<em>E</em>)-Bisdemethoxycurcumin
  • HY-B0779A

    (5E,9E,13E)-Geranylgeranylacetone

    HSP Metabolic Disease
    (5E,9E,13E)-Teprenone ((5E,9E,13E)-Geranylgeranylacetone) is an isomer of Teprenone with antiulcer activity. (5E,9E,13E)-Teprenone induces transcriptional activation of HSP genes that may increase gastric mucosal defense at conditions of stress .
    (5<em>E</em>,9<em>E</em>,13<em>E</em>)-Teprenone
  • HY-N1378
    (E)-Cardamonin
    1 Publications Verification

    (E)-Cardamomin; (E)-Alpinetin chalcone

    TRP Channel Apoptosis Neurological Disease Cancer
    (E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.
    (<em>E</em>)-Cardamonin
  • HY-15282
    E-64
    5+ Cited Publications

    Proteinase inhibitor E 64

    Cathepsin Autophagy Bacterial Inflammation/Immunology Cancer
    E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain.
    <em>E</em>-64
  • HY-10082A

    (E)-PAN-811; (E)-NSC# 663249; (E)-OCX191

    DNA/RNA Synthesis Cancer
    (E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis .
    (<em>E</em>)-3-AP
  • HY-10016
    E 2012
    5+ Cited Publications

    γ-secretase Neurological Disease
    E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat .
    <em>E</em> 2012
  • HY-N0860

    Schizantherin-E

    Others Inflammation/Immunology
    Schisantherin E is a natural compound isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.
    Schisantherin <em>E</em>
  • HY-N0060B

    (E)-Coniferic acid

    (E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.
    (<em>E</em>)-Ferulic acid
  • HY-N2519

    (E)-Laricin

    Fungal Infection
    (E)-Coniferin is the isomer of Coniferin. Coniferin is a glucoside of coniferyl alcohol. Coniferin inhibits fungal growth and melanization .
    (<em>E</em>)-Coniferin
  • HY-128978

    Phosphatase Metabolic Disease
    (E,E)-RAMB4 is a potent and selective potent protein tyrosine phosphatase-1B (PTP1B) inhibitor extracted from patent CN103626692A, example 1 .
    (<em>E</em>,<em>E</em>)-RAMB4
  • HY-N3509

    (-)-Hyponine E

    Others Inflammation/Immunology
    Hyponine E, a macrocyclic sesquiterpene pyridine alkaloid that could be isolated from from Tripterygium hypoglaucum, possesses anti-inflammatory effects .
    Hyponine <em>E</em>
  • HY-N7781

    (E)-Guggulsterone

    Drug Metabolite Metabolic Disease
    (-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic agent derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity .
    (-)-(<em>E</em>)-Guggulsterone
  • HY-115918

    Xanthoangelol E

    Others Infection
    XA-E is a compound purified from a methanol-ethyl acetate extract from A. keiskei. XA-E displays anti-ZIKV activity with an IC50 value of 22.0 µM .
    XA-<em>E</em>
  • HY-N3371

    (-)-Longikaurin E

    Others Others
    Longikaurin E is a diterpenoids compound isolated from the leaves of Rabdosia ternifolia (D. Don) .
    Longikaurin <em>E</em>
  • HY-N3633

    (+)-Coronarin E

    Others Others
    Coronarin E is a compound isolated from the rhizome of Hedychium coronarium (Zingiberaceae) .
    Coronarin <em>E</em>
  • HY-W019710

    HDAC Neurological Disease
    (E,E)-RGFP966 is a selective and CNS permeable HDAC3 inhibitor that can be used for the research of Huntington’s disease .
    (<em>E</em>,<em>E</em>)-RGFP966
  • HY-121582

    (E)-EPH 116

    Others Cancer
    (E)-SI-2 is an isomer of SI-2, an inhibitor of the steroid receptor coactivator SRC-3. SI-2 has anticancer activity and increases the number of cytotoxic immune cells in mice with breast cancer .
    (<em>E</em>)-SI-2
  • HY-100962

    (E)-Tyrphostin 46; (E)-Tyrphostin AG 99

    (E)-AG 99 ((E)-Tyrphostin 46) is a potent EGFR inhibitor .
    (<em>E</em>)-AG 99
  • HY-18719D

    E-Endoxifen

    Estrogen Receptor/ERR Cancer
    Endoxifen E-isomer (E-Endoxifen), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer exhibits antiestrogenic effects .
    Endoxifen (<em>E</em>-isomer)
  • HY-13650
    Indisulam
    5 Publications Verification

    E 7070

    Molecular Glues Carbonic Anhydrase Cancer
    Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15 .
    Indisulam
  • HY-16950B

    (E)-Afimoxifene

    Estrogen Receptor/ERR Cancer
    (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator.
    (<em>E</em>)-4-Hydroxytamoxifen
  • HY-18719C

    E-Endoxifen hydrochloride

    Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects .
    Endoxifen <em>E</em>-isomer hydrochloride
  • HY-19384

    E 6087

    Enflicoxib (E 6087) is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2 (COX-2). Enflicoxib does not inhibit cyclooxygenase-1 (COX-1). E-6087 shows anti-inflammatory, analgesic and antipyretic activities in animal models .
    Enflicoxib
  • HY-W263279

    (E)-Wy-8678

    Adrenergic Receptor Cardiovascular Disease Neurological Disease
    (E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease .
    (<em>E</em>)-Guanabenz
  • HY-N10751

    Bacterial Infection
    (2E,4E)-Decadienoic acid is an anti-oomycete aliphatic compound that can be found in Coculture of Bacillus subtilis and Trichoderma asperellum .
    (2<em>E</em>,4<em>E</em>)-Decadienoic acid
  • HY-B1234A

    (E)-Octyl methoxycinnamate

    Estrogen Receptor/ERR Androgen Receptor Endocrinology
    (E)-Octinoxate is the isomer of Octinoxate (HY-B1234). Octinoxate is an organic compound that is an ingredient in some sunscreens and lip balms, primarily used is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage and can be used to reduce the appearance of scars. Octinoxate also has a complex androgenic and estrogenic effect .
    (<em>E</em>)-Octinoxate
  • HY-113102A

    Endogenous Metabolite Cancer
    9(E),11(E)-Octadecadienoic acid is an isomer of conjugated linoleic acid (CLA). Conjugated linoleic acid is a fatty acid with potentially beneficial physiological and anticarcinogenic effects .
    9(<em>E</em>),11(<em>E</em>)-Octadecadienoic acid
  • HY-N1214A

    (E/Z)-Super Squalene; (E/Z)-AddaVax

    Apoptosis Cancer
    (E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner .
    (<em>E</em>/Z)-Squalene
  • HY-15166
    (E/Z)-Zotiraciclib
    5 Publications Verification

    (E/Z)-TG02; (E/Z)-SB1317

    CDK JAK FLT3 Cancer
    (E/Z)-Zotiraciclib ((E/Z)-TG02) is a potent inhibitor of CDK2, JAK2 and FLT3 with IC50s of 13, 73 and 56 nM, respectively. (E/Z)-Zotiraciclib effectively inhibits the proliferation of cancer cells, it can be used for the research of cancer .
    (<em>E</em>/Z)-Zotiraciclib
  • HY-15166A
    (E/Z)-Zotiraciclib hydrochloride
    5 Publications Verification

    (E/Z)-TG02 hydrochloride; (E/Z)-SB1317 hydrochloride

    CDK JAK FLT3 Cancer
    (E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride is a potent CDK2, JAK2, and FLT3 inhibitor .
    (<em>E</em>/Z)-Zotiraciclib hydrochloride
  • HY-18956

    (E/Z)-Sephin1; (E/Z)-IFB-088

    (E/Z)-Icerguastat ((E/Z)-Sephin1) is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). (E/Z)-Icerguastat can be used for protein misfolding diseases research .
    (<em>E</em>/Z)-Icerguastat
  • HY-10261B

    (E/Z)-BIBW 2992

    (E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells .
    (<em>E</em>/Z)-Afatinib
  • HY-Y1311
    Malic acid
    1 Publications Verification

    Hydroxybutanedioic acid; E 296

    Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods.
    Malic acid
  • HY-N0120

    (E/Z)-Piceid

    Others Inflammation/Immunology
    (E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions .
    (<em>E</em>/Z)-Polydatin
  • HY-122895A

    Apoptosis PDI Cancer
    (E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity .
    (<em>E</em>/Z)-<em>E</em>64FC26
  • HY-W018643A

    Methyl (E)-ferulate

    Others Others
    (E)-Ferulic acid methyl ester (Methyl (E)-ferulate) exhibits strong DPPH and ABTS + radical scavenging activities .
    (<em>E</em>)-Ferulic acid methyl ester
  • HY-14971
    (E)-Akt inhibitor-IV
    1 Publications Verification

    (E)-AKTIV

    Akt Cancer
    (E)-Akt inhibitor-IV ((E)-AKTIV) is a PI3K-Akt inhibitor, with potent cytotoxic .
    (<em>E</em>)-Akt inhibitor-IV
  • HY-108516

    PARP Cancer
    TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively .
    TC-<em>E</em> 5001
  • HY-107574

    Histone Methyltransferase Inflammation/Immunology
    TC-E 5003 is a selective PRMT1 inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 has anti-inflammatory properties in TLR4 signaling .
    TC-<em>E</em> 5003
  • HY-133159

    (-)-Resolvin E2

    Others Inflammation/Immunology
    Resolvin E2 ((-)-Resolvin E2), a proresolving lipid mediator, is useful as a lead for anti-inflammatory agent .
    Resolvin <em>E</em>2
  • HY-N1611

    (E)-Vallesamine

    Others Others
    19,20-(E)-Vallesamine is an indole alkaloid compound isolated from the stems of Ervatamia yunnanensis .
    19,20-(<em>E</em>)-Vallesamine
  • HY-N1641

    Deacetylkhayanolide E

    Others Others
    1-O-Deacetylkhayanolide E is a khayanolide, which can be isolated from the stem bark of African mahogany Khaya senegalensis .
    1-O-Deacetylkhayanolide <em>E</em>
  • HY-10568

    Phosphodiesterase (PDE) Metabolic Disease
    TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 values of 7.28, 239, 779, 919, 3,100, and 3,700 nM for PDE10A, 2A, 11A, 5A, 7B and 3A, respectively. TC-E 5005 inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate .
    TC-<em>E</em> 5005
  • HY-110144

    Isocitrate Dehydrogenase (IDH) Cancer
    TC-E 5008 is a potent mutant IDH1 inhibitor with Ki values of 190 nM and 120 nM for R132H and R132C IDH1 mutants, respectively. TC-E 5008 exhibits very weak activity against WT-IDH1 with a Ki value of 12.3 μM. TC-E 5008 has anti-proliferative activity on multiple ER positive breast cancer cell lines .
    TC-<em>E</em> 5008
  • HY-50108A

    FXR Others
    (E)-GW 4064 is a FXR agonist .
    (<em>E</em>)-GW 4064
  • HY-N7781R

    (E)-Guggulsterone (Standard)

    Drug Metabolite Metabolic Disease
    (-)-(E)-Guggulsterone (Standard) is the analytical standard of (-)-(E)-Guggulsterone. This product is intended for research and analytical applications. (-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic agent derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity .
    (-)-(<em>E</em>)-Guggulsterone (Standard)
  • HY-101041

    (E)-Tyrphostin AG 556

    (E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production .
    (<em>E</em>)-AG 556
  • HY-B0265
    Nimodipine
    5+ Cited Publications

    BAY-e 9736

    Autophagy Calcium Channel Cardiovascular Disease Cancer
    Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders .
    Nimodipine
  • HY-B1151

    BAY-e 6975

    Fungal Infection
    Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450 .
    Climbazole
  • HY-N5097

    PPAR Metabolic Disease
    13-Oxo-9E,11E-octadecadienoic acid, an isomer of 9-oxo-ODA, is a potent PPARα activator derived from tomato juice. 13-Oxo-9E,11E-octadecadienoic acid decreases plasma and hepatic triglyceride in obese diabetic mice .
    13-Oxo-9<em>E</em>,11<em>E</em>-octadecadienoic acid

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