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Cat. No.: HY-121582

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(E)-SI-2

(Synonyms: (E)-EPH 116)

(E)-SI-2 is an isomer of SI-2, an inhibitor of the steroid receptor coactivator SRC-3. SI-2 has anticancer activity and increases the number of cytotoxic immune cells in mice with breast cancer.

For research use only. We do not sell to patients.

CAS No.: 380537-35-9
Formula: C₁₅H₁₅N₅
Molecular Weight:265.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

(E)-SI-2 Chemical Structure

CAS No.: 380537-35-9

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Sample (0.1mg)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

(E)-SI-2 is an isomer of SI-2, an inhibitor of the steroid receptor coactivator SRC-3. SI-2 has anticancer activity and increases the number of cytotoxic immune cells in mice with breast cancer^[1].

IC₅₀ & Target

SRC-3^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
TOV112D	EC₅₀	0.004 μM Compound: C9	Growth inhibition of human TOV112D cells harbouring p53 R175H mutant incubated for 3 days by MTS assay Growth inhibition of human TOV112D cells harbouring p53 R175H mutant incubated for 3 days by MTS assay	[PMID: 33538587]

Chemical Information

CAS No. 380537-35-9
Molecular Weight 265.31
Formula C₁₅H₁₅N₅
SMILES

CN1C2=CC=CC=C2N=C1N/N=C(C3=CC=CC=N3)\C
Synonyms

(E)-EPH 116
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Han SJ, et al. Steroid receptor coactivator-3 inhibition generates breast cancer antitumor immune microenvironment. Breast Cancer Res. 2022 Oct 31;24(1):73. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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