2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. (E)-3-AP

(E)-3-AP  (Synonyms: (E)-PAN-811; (E)-NSC# 663249; (E)-OCX191)

Cat. No.: HY-10082A Purity: 99.24%
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(E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis.

For research use only. We do not sell to patients.

(E)-3-AP

(E)-3-AP Chemical Structure

CAS No. : 200933-27-3

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Based on 1 publication(s) in Google Scholar

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(E)-3-AP Related Antibodies

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Description

(E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2].

In Vitro

3-AP shows anti-proliferative activity with IC50 values of 1.3, 1.6 µM for L1210, L1210/HUr cells, respectively[1].
3-AP (5, 10, 15, 20, 30 mg/kg; i.p.; twice daily for six consecutive days) significantly increases in life span were observed with each dosage employed and long term survivors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(E)-3-AP Related Antibodies
Molecular Weight

195.24

Formula

C7H9N5S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC1=CC=CN=C1/C=N/NC(N)=S.[(E)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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(E)-3-AP Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-3-AP200933-27-3(E)-PAN-811 (E)-NSC# 663249 (E)-OCX191DNA/RNA SynthesisL1210 leukemia cellsanti-proliferativeanticancerDNA synthesisInhibitorinhibitorinhibit

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