200933-27-3
200933-27-3
Chemical Structure
(E)-3-AP
Synonym(s): (E)-PAN-811; (E)-NSC# 663249; (E)-OCX191
- CAS No.: 200933-27-3
- Formula:C7H9N5S
- Molecular Weight:195.24
IUPAC Name: (E)-2-((3-aminopyridin-2-yl)methylene)hydrazine-1-carbothioamide
InChIKey: XMYKNCNAZKMVQN-NYYWCZLTSA-N
SMILES: NC1=CC=CN=C1/C=N/NC(N)=S.[(E)]
Biological Activity: (E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(E)-3-AP | 99.24% | (E)-3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis. | ||||||||||||||||||||
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References
- [1]. Finch RA, et al. Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv Enzyme Regul. 1999;39:3-12. [Content Brief]
- [2]. Enyedy ÉA ,et al. Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation. Dalton Trans. 2020 Dec 8;49(46):16887-16902. [Content Brief]
Keywords
