Cat. No.: HY-18651

(E/Z)-Rigosertib sodium

(Synonyms: (E/Z)-ON-01910 sodium)

Rigosertib (ON-01910) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

CAS No.: 1225497-78-8
Formula: C₂₁H₂₄NNaO₈S
Molecular Weight:473.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

(E/Z)-Rigosertib sodium Chemical Structure

CAS No.: 1225497-78-8

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Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Rigosertib (ON-01910) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

IC₅₀ & Target

PLK1

All Polo-like Kinase (PLK) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
2008	IC₅₀	0.15 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human 2008 cells assessed as cell viability after 96 hrs by trypan blue exclusion Cytotoxicity against human 2008 cells assessed as cell viability after 96 hrs by trypan blue exclusion	[PMID: 21812421]
A2780	GI₅₀	0.04 μM Compound: Rigosertib Sodium	Antiproliferative activity against human A2780 cells measured after 72 hrs by MTT assay Antiproliferative activity against human A2780 cells measured after 72 hrs by MTT assay	[PMID: 27815119]
A549	IC₅₀	0.09 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human A549 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human A549 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
AGS	IC₅₀	0.08 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human AGS cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human AGS cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
Bel-7402	IC₅₀	0.1 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human Bel7402 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human Bel7402 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
BT-20	IC₅₀	0.08 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human BT20 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human BT20 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
BT-474	IC₅₀	0.05 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human BT474 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human BT474 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
BXPC-3	IC₅₀	0.075 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human BxPC3 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human BxPC3 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
CCRF-CEM	IC₅₀	0.1 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human CEM cells assessed as cell viability after 96 hrs by trypan blue exclusion Cytotoxicity against human CEM cells assessed as cell viability after 96 hrs by trypan blue exclusion	[PMID: 21812421]
CEM/C2	IC₅₀	0.05 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against multidrug-resistant human CEM/C2 cells assessed as cell viability after 96 hrs by trypan blue exclusion Cytotoxicity against multidrug-resistant human CEM/C2 cells assessed as cell viability after 96 hrs by trypan blue exclusion	[PMID: 21812421]
COLO 205	IC₅₀	0.15 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human COLO205 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human COLO205 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
COLO 320	IC₅₀	0.06 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human COLO320 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human COLO320 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
Daudi	IC₅₀	0.15 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human Daudi cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human Daudi cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
DLD-1	IC₅₀	0.15 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human DLD1 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human DLD1 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
DU-145	IC₅₀	0.1 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human DU145 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human DU145 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
Granta-519	IC₅₀	0.075 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human GRANTA-519 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human GRANTA-519 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
HCC70	IC₅₀	0.075 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human HCC70 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human HCC70 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
HCT-116	GI₅₀	0.06 μM Compound: Rigosertib Sodium	Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells measured after 72 hrs by MTT assay	[PMID: 27815119]
HCT-116	IC₅₀	0.01 μM Compound: 1; ON01910	Cytotoxicity against human HCT-116 cells Cytotoxicity against human HCT-116 cells	[PMID: 35305462]
HCT-116	IC₅₀	0.075 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human HCT116 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human HCT116 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
HCT-15	IC₅₀	0.09 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human HCT15 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human HCT15 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
HEL	IC₅₀	0.05 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human HEL cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human HEL cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
HeLa	IC₅₀	0.01 μM Compound: 1; ON01910	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 35305462]
HeLa	IC₅₀	0.1 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human HeLa cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human HeLa cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
HepG2	IC₅₀	0.01 μM Compound: 1; ON01910	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 35305462]
HL-60	IC₅₀	0.02 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human HL60 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human HL60 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
HUVEC	IC₅₀	>100 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against HUVEC after 96 hrs by trypan blue exclusion assay Cytotoxicity against HUVEC after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
K562	IC₅₀	0.015 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human K562 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human K562 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
KB	IC₅₀	0.07 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human KB cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human KB cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
KG-1a	IC₅₀	0.03 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human KG1a cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human KG1a cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
LP-1	IC₅₀	0.03 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human LP-1 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human LP-1 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
MCF7	IC₅₀	0.01 μM Compound: 1; ON01910	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 35305462]
MCF7	IC₅₀	0.075 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human MCF7 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human MCF7 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
MDA-MB-157	IC₅₀	0.075 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human MDA-MB-157 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human MDA-MB-157 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
MDA-MB-231	IC₅₀	0.025 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human MDA-MB-231 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human MDA-MB-231 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
MES-SA	IC₅₀	0.1 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human MES-SA cells assessed as cell viability after 96 hrs by trypan blue exclusion Cytotoxicity against human MES-SA cells assessed as cell viability after 96 hrs by trypan blue exclusion	[PMID: 21812421]
MES-SA/Dx5	IC₅₀	0.1 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against multidrug-resistant human MES-SA/Dx5 cells assessed as cell viability after 96 hrs by trypan blue exclusion Cytotoxicity against multidrug-resistant human MES-SA/Dx5 cells assessed as cell viability after 96 hrs by trypan blue exclusion	[PMID: 21812421]
MIA PaCa-2	IC₅₀	0.05 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human MIAPaCa2 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human MIAPaCa2 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
MOLT-4	IC₅₀	0.04 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human MOLT4 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human MOLT4 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
NAMALVA	IC₅₀	0.075 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human NAMALWA cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human NAMALWA cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
NCI-H1299	IC₅₀	0.01 μM Compound: 1; ON01910	Cytotoxicity against human NCI-H1299 cells Cytotoxicity against human NCI-H1299 cells	[PMID: 35305462]
NCI-H157	IC₅₀	0.08 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human NCI-H157 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human NCI-H157 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
NCI-H187	IC₅₀	0.08 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human NCI-H187 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human NCI-H187 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
NCI-H1975	IC₅₀	0.09 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human NCI-H1975 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human NCI-H1975 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
NCI-H417	IC₅₀	0.08 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human NCI-N417 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human NCI-N417 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
OPM-2	IC₅₀	0.015 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human OPM2 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human OPM2 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
OVCAR-3	IC₅₀	0.075 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human OVCAR3 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human OVCAR3 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
PANC-1	IC₅₀	0.04 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human PANC1 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human PANC1 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
PC-3	IC₅₀	0.15 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human PC3 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human PC3 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
Raji	IC₅₀	0.075 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human Raji cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human Raji cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
RPMI-7951	IC₅₀	0.025 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human RPMI7951 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human RPMI7951 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
SK-BR-3	IC₅₀	0.075 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human SKBR3 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human SKBR3 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
SW480	IC₅₀	0.06 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human SW480 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human SW480 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
T47D	IC₅₀	0.17 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human T47D cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human T47D cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
U-266	IC₅₀	0.025 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human U266 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human U266 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
U-87MG ATCC	IC₅₀	0.08 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human U87 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human U87 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
U-937	IC₅₀	0.01 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human U937 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human U937 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]
WM793	IC₅₀	0.075 μM Compound: 28, ON 01910.Na, ESTYBON	Cytotoxicity against human WM793 cells after 96 hrs by trypan blue exclusion assay Cytotoxicity against human WM793 cells after 96 hrs by trypan blue exclusion assay	[PMID: 21812421]

In Vitro

Rigosertib (ON-01910) sodium is a non-ATP competitive PLK1 inhibitor with IC50 of 9 nM, 30-fold selectivity over Plk2, no inhibitory activity against Plk3.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1225497-78-8
Molecular Weight 473.47
Formula C₂₁H₂₄NNaO₈S
SMILES

O=C(CNC1=CC(CS(=O)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O)=CC=C1OC)O[Na]
Synonyms

(E/Z)-ON-01910 sodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gumireddy K, et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005 Mar;7(3):275-86. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(E/Z)-Rigosertib sodium

All Polo-like Kinase (PLK) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(E/Z)-Rigosertib sodium Related Classifications

HY-18651 Related Classifications