1. Stem Cell/Wnt
    Apoptosis
    Metabolic Enzyme/Protease
  2. β-catenin
    Bcl-2 Family
    Ferroptosis
    Endogenous Metabolite
  3. (E)-Ferulic acid

(E)-Ferulic acid (Synonyms: (E)-Coniferic acid)

Cat. No.: HY-N0060B Purity: 99.20%
Handling Instructions

(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299.

For research use only. We do not sell to patients.

(E)-Ferulic acid Chemical Structure

(E)-Ferulic acid Chemical Structure

CAS No. : 537-98-4

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10 mM * 1  mL in DMSO USD 55 In-stock
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100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

(E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].

IC50 & Target

Bax

 

Human Endogenous Metabolite

 

Molecular Weight

194.18

Formula

C₁₀H₁₀O₄

CAS No.

537-98-4

SMILES

O=C(O)/C=C/C1=CC=C(O)C(OC)=C1.[(E)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (514.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1499 mL 25.7493 mL 51.4986 mL
5 mM 1.0300 mL 5.1499 mL 10.2997 mL
10 mM 0.5150 mL 2.5749 mL 5.1499 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(E)-Ferulic acid(E)-Coniferic acidβ-cateninBcl-2 FamilyFerroptosisEndogenous MetaboliteBeta cateninInhibitorinhibitorinhibit

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(E)-Ferulic acid
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HY-N0060B
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