Cat. No.: HY-N0060A

Ferulic acid sodium

(Synonyms: Coniferic acid sodium)

19 Cited Publications

Customer Review

Based on 19 publication(s) in Google Scholar

Ferulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

For research use only. We do not sell to patients.

Purity: 99.88%
CAS No.: 24276-84-4
Formula: C₁₀H₉NaO₄
Molecular Weight:216.17

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Ferulic acid sodium Chemical Structure

CAS No.: 24276-84-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (19)
Solvent & Solubility
- In Vitro
- In Vivo
Protocol
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Ferulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

IC₅₀ & Target

IC50: 3.78 μM (FGFR1), 12.5 μM (FGFR2)^[1].

All Endogenous Metabolite Isoforms :

In Vitro

Ferulic acid (FA) is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC₅₀s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively. Ferulic acid exhibits great inhibitory activity on FGFR1 with an inhibitory rate of 92% at 1 μM. The proliferation of HUVEC stimulated by FGF1 is markedly decreased after Ferulic acid treatment ranging from 5 to 40 μM for 24 h. Ferulic acid does not exert significant cell viability up to 20 μM, but over 30 μM Ferulic acid exhibits a cytotoxic effect in HUVEC compare to the control. Ferulic acid inhibits FGF1-induced HUVEC migration and invasion in a dose-dependent manner. Ferulic acid markedly suppresses the FGF1-induced phosphorylation of PI3K and Akt. Ferulic acid treatments significantly inhibit MMP-2 and MMP-9 expression stimulated by FGF1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Treatment with Ferulic acid (FA) potently inhibits FGF1-induced neovascularization. It is found that intragastric administration of Ferulic acid markedly inhibits tumor volume and tumor weight, as compare to the counterparts treated with DMSO. Furthermore, Ferulic acid treatment is well tolerated, and there is no significant difference in weight between the vehicle group and the FA-treated groups^[1]. Ferulic acid (0.01, 0.1, 1 or 10 mg/kg) given by oral route decreases significantly the immobility time in the forced swimming test (FST) and tail suspension test (TST), whereas produces no effect in the open-field test. Results demonstrate that the administration of Ferulic acid (0.001 mg/kg, p.o.) boosts the antidepressant-like effect of fluoxetine (5 mg/kg, p.o.) in the TST^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 24276-84-4
Appearance Solid
Molecular Weight 216.17
Formula C₁₀H₉NaO₄
Color Off-white to yellow
SMILES

O=C(O[Na])/C=C/C1=CC=C(O)C(OC)=C1
Synonyms

Coniferic acid sodium
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
- Phenols
- Monophenols
Initial Source
- Plants
- other families
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (19)

All Cell Proliferation/Viability AssayBio/Physico-chemical AssayHistological Imaging/StainingWBELISAIF

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Phytomedicine

Bioactive equivalent combinatorial components of Xiao-Xu-Ming decoction inhibit the calmodulin-mediated MLCK/MLC axis to attenuate coronary artery spasm. [Abstract]

2025 Jul:142:156713. PMID: 40349422
Phytomedicine

Herbal-based Xuebijing injection ameliorated vascular endothelial dysfunction via inhibiting ACLY/MYB/RIG-I axis in sepsis-associated lung injury. [Abstract]

2025 May:140:156573. PMID: 40088739

Ferulic acid sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156573. [Abstract]

HPLC chromatogram of Ferulic Acid.

Ferulic acid sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 May:140:156573. [Abstract]

Ferulic Acid (FA, 100 μM; 4 h) effectively inhibited LPS-induced upregulation of E-selectin, VCAM-1, TF and PAI-1 in HUVEC.
Food Chem

Discovery of novel ascorbic acid derivatives and other metabolites in fruit of Rosa roxburghii Tratt through untargeted metabolomics and feature-based molecular networking. [Abstract]

2023 Mar 30;405(Pt A):134807. PMID: 36370576
Free Radic Biol Med

Ferulic acid attenuates Sarcopenia progression by inhibiting peroxisomal ACOX1. [Abstract]

2025 Aug 13:240:183-196. PMID: 40816648

Ferulic acid sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Aug 13:240:183-196. [Abstract]

Effects of different concentrations of Ferulic acid (FA, 10, 50, 200, 500 μg/mL) and/or Dex (20 μM) continuously treated for 48 h on the proliferative vigor of C2C12 cells (CCK-8 assay). The results showed that compared with dexamethasone (Dex) treatment, FA (1–50 μg/mL; 48 h) treatment tended to promote the proliferative activity of C2C12 cells. Furthermore, FA (50 μg/mL) significantly reversed the decrease in proliferative activity of C2C12 cells induced by Dex treatment.

Ferulic acid sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Aug 13:240:183-196. [Abstract]

Myotube(dark blue) morphology of each group after 72 h of treatment with Gimsa staining. Gimsa staining showed that the diameter and number of myotube decreased after Dexamethasone (Dex) treatment and recovered after Ferulic acid (FA, 10-200 μg/mL; 72 h) intervention.

Ferulic acid sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Aug 13:240:183-196. [Abstract]

Effects of different concentrations of Ferulic acid (FA,10, 50, 200 μg/ml) and/or Dexamethasone (Dex, 20 μM) on the levels of inflammatory factors TNF-α, IL-6 in the supernatant of C2C12 cell culture after 72 h of continuous treatment. The results showed that FA (10–200 μg/mL) could reduce the levels of TNF-α and IL-6 in the Dex group, with the effects being more significant at concentrations of 50 μg/mL and 200 μg/mL, indicating that FA inhibits sarcopenia-associated inflammation.

Ferulic acid sodium purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Aug 13:240:183-196. [Abstract]

Immunofluorescence technique was used to detect the expression of ACOX1 at different concentrations of Ferulic acid (FA) (50, 200 μg/ml) and/or Dexamethasone (Dex) (20 μM) after 72 h of continuous treatment (200 × ). NC: Normal Control group; Dex: Model group; FA: Model + FA group. Immunofluorescence assay showed that ACOX1 was significantly reduced after Ferulic acid (FA) (200 μg/mL) intervention compared with the Dex group.
Neurotherapeutics

Ferulic Acid Improves Synaptic Plasticity and Cognitive Impairments by Alleviating the PP2B/DARPP-32/PP1 Axis-Mediated STEP Increase and Aβ Burden in Alzheimer's Disease. [Abstract]

2023 Jul;20(4):1081-1108. PMID: 37079191

Ferulic acid sodium purchased from MedChemExpress. Usage Cited in: Neurotherapeutics. 2023 Jul;20(4):1081-1108. [Abstract]

Ferulic acid (FA; 5, 10 μM; 2 h) restores the Aβ-induced decreased expression of p-Y416 and increased expression of npS221 in neuronal cells.
CNS Neurosci Ther

Tongqiao Huoxue Decoction ameliorates traumatic brain injury-induced gastrointestinal dysfunction by regulating CD36/15-LO/NR4A1 signaling, which fails when CD36 and CX3CR1 are deficient. [Abstract]

2023 Jun;29 Suppl 1(Suppl 1):161-184. PMID: 37157929
Eur J Pharmacol

Sodium ferulate prevents breast cancer metastasis by remodeling the bloodstream microenvironment. [Abstract]

2026 Jun 25:1030:179092. PMID: 42349818
Pharmaceuticals (Basel)

Bruceine D Identified as a Drug Candidate against Breast Cancer by a Novel Drug Selection Pipeline and Cell Viability Assay. [Abstract]

2022 Jan 31;15(2):179. PMID: 35215292
Arab J Chem

2024 Aug.
Biol Proced Online

Establishment of a mouse lung cancer organoid model and its applications for therapeutic screening. [Abstract]

2025 Jun 16;27(1):21. PMID: 40524168
Brain Res Bull

Ferulic acid promotes proliferation and angiogenesis of cerebral microvascular endothelial cells in Moyamoya disease via the SIRT1/HIF-1α/VEGF-A axis. [Abstract]

2026 Jun 1:239:111886. PMID: 41980628
Biomedicines

Ferulic Acid Alleviates Chemotherapy-Induced POI by Targeting the Grp78 and Perk-eIF2α-ATF4-CHOP Pathway to Attenuate Endoplasmic Reticulum Stress. [Abstract]

2026 Mar 19;14(3):714. PMID: 41898358
Fish Shellfish Immunol

Emodin enhances host antiviral immunity against Micropterus salmoides rhabdovirus by activating RLR signaling in largemouth bass. [Abstract]

2025 Aug 6:166:110633. PMID: 40769268
J Bioenerg Biomembr

Ferulic acid relieves hypoxic damage by inhibiting endoplasmic reticulum stress, oxidative stress, and apoptosis through activating FOXA2-modulated Nrf2/HO-1 pathway in spermatogonial cells. [Abstract]

2026 Mar 24;58(1):4. PMID: 41874733
Stem Cells Int

Ferulic Acid Alleviates Inflammation and Promotes Osteogenic Differentiation in Periodontitis by Inhibiting NF- κ B Pathway. [Abstract]

2025 Dec 17:2025:1891956. PMID: 41497811
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Bull Mater Sci

2026 Jun 16;49(3):114.
Appl Bionics Biomech

Ferulic Acid Protects Endothelial Cells from Hypoxia-Induced Injury by Regulating MicroRNA-92a. [Abstract]

2022 Jul 31:2022:6148361. PMID: 35959508
Research Square Preprint

2024 Dec 17.

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (462.60 mM; Need ultrasonic)

DMSO : 33.33 mg/mL (154.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.6260 mL

23.1299 mL

46.2599 mL

5 mM

0.9252 mL

4.6260 mL

9.2520 mL

10 mM

0.4626 mL

2.3130 mL

4.6260 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (11.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (11.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 33.33 mg/mL (154.18 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Protocol

Cell Assay^[1]

HUVEC (5×10⁴ cells/well) are plated onto a gelatinized 24-well culture plate and cultured in ECGS containing 15% FBS. HUVEC are treated with DMSO (0.1%) or different concentrations of Ferulic acid (FA) (0, 2.5, 5, 10, 20, 30, 40 μM) for 24 h. Cell viability is determined by the MTT assay. After 4 h of incubation, the absorbance is measured at 450 nm with a microplate reader. The results are calculated from six replicates of each experiment. Three independent experiments are performed^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[2]

Male Swiss mice (30 to 40 g) are maintained at 21 to 23°C with free access to water and food, under a 12:12 h light/dark cycle (lights on at 07:00 h). All manipulations are carried out between, 9:00 and 16:00 h, with each animal used only once. In order to investigate the antidepressant-like effect of Ferulic acid, Ferulic acid is administered at a dose range of 0.001 to 10 mg/kg, by oral route (p.o.) 60 min before the forced swimming test (FST), tail suspension test (TST) or open-field test. The control animals receive appropriate vehicle^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang GW, et al. Ferulic Acid Exerts Anti-Angiogenic and Anti-Tumor Activity by Targeting Fibroblast Growth Factor Receptor 1-Mediated Angiogenesis. Int J Mol Sci. 2015 Oct 12;16(10):24011-31. [Content Brief]

[2]. Zeni AL, et al. Ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: evidence for the involvement of the serotonergic system. Eur J Pharmacol. 2012 Mar 15;679(1-3):68-74. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	4.6260 mL	23.1299 mL	46.2599 mL	115.6497 mL
	5 mM	0.9252 mL	4.6260 mL	9.2520 mL	23.1299 mL
	10 mM	0.4626 mL	2.3130 mL	4.6260 mL	11.5650 mL
	15 mM	0.3084 mL	1.5420 mL	3.0840 mL	7.7100 mL
	20 mM	0.2313 mL	1.1565 mL	2.3130 mL	5.7825 mL
	25 mM	0.1850 mL	0.9252 mL	1.8504 mL	4.6260 mL
	30 mM	0.1542 mL	0.7710 mL	1.5420 mL	3.8550 mL
	40 mM	0.1156 mL	0.5782 mL	1.1565 mL	2.8912 mL
	50 mM	0.0925 mL	0.4626 mL	0.9252 mL	2.3130 mL
	60 mM	0.0771 mL	0.3855 mL	0.7710 mL	1.9275 mL
	80 mM	0.0578 mL	0.2891 mL	0.5782 mL	1.4456 mL
	100 mM	0.0463 mL	0.2313 mL	0.4626 mL	1.1565 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Ferulic acid sodium

19 Cited Publications

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Ferulic acid sodium

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Publications Citing Use of MedChemExpress (MCE) Ferulic acid sodium

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (19)

Solvent & Solubility

Protocol

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Ferulic acid sodium Related Classifications