2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. (E/Z)-Sivopixant

(E/Z)-Sivopixant  (Synonyms: (E/Z)-S-600918)

Cat. No.: HY-137451A Purity: 98.64% ee.: 99.14%
COA Handling Instructions

(E/Z)-Sivopixant ((E/Z)-S-600918) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.

For research use only. We do not sell to patients.

(E/Z)-Sivopixant Chemical Structure

(E/Z)-Sivopixant Chemical Structure

CAS No. : 1640808-39-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 503 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 503 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

(E/Z)-Sivopixant ((E/Z)-S-600918) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research[1].

IC50 & Target

IC50: 4 nM (P2X3 receptor)[1]
In Vitro

ATP receptors are roughly classified into an ion channel type P2X family and a G protein coupled type P2Y family. Seven types of subtypes have been reported in the P2X receptor family, and function as non-selective cation channels by forming homotrimers or heterotrimers with other P2X subtypes. Furthermore, P2X3 that the receptor is expressed in neuroepithelial bodies (NEB) of the lungs, and ATP-induced cough, etc., P2X3 receptors. It has been suggested that it is involved in information transmission in the respiratory organs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

507.93

Appearance

Solid

Formula

C25H22ClN5O5
CAS No.
SMILES

O=C(N(C1=O)C[[email protected]](C)C(O)=O)N=C(NC2=CC=C(C=C2)OC3=CC=CC=N3)N1CC4=CC=C(C=C4)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9688 mL 9.8439 mL 19.6878 mL
5 mM 0.3938 mL 1.9688 mL 3.9376 mL
10 mM 0.1969 mL 0.9844 mL 1.9688 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.92 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.92 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.64% ee.: 99.14%

COA (253 KB) HNMR (286 KB) NP-HPLC (239 KB) LCMS (265 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(E/Z)-Sivopixant1640808-39-4(E/Z)-S-600918P2X ReceptorP2XRsP2X3respiratorydiseasescoughInhibitorinhibitorinhibit

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