1. Membrane Transporter/Ion Channel
  2. P2X Receptor
  3. (E/Z)-Sivopixant

(E/Z)-Sivopixant 

Cat. No.: HY-137451A Purity: 98.64% ee.: 99.14%
Handling Instructions

(E/Z)-Sivopixant (Compound I-127) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.

For research use only. We do not sell to patients.

(E/Z)-Sivopixant Chemical Structure

(E/Z)-Sivopixant Chemical Structure

CAS No. : 1640808-39-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 503 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

(E/Z)-Sivopixant (Compound I-127) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research[1].

IC50 & Target

IC50: 4 nM (P2X3 receptor)[1]

In Vitro

ATP receptors are roughly classified into an ion channel type P2X family and a G protein coupled type P2Y family. Seven types of subtypes have been reported in the P2X receptor family, and function as non-selective cation channels by forming homotrimers or heterotrimers with other P2X subtypes. Furthermore, P2X3 that the receptor is expressed in neuroepithelial bodies (NEB) of the lungs, and ATP-induced cough, etc., P2X3 receptors It has been suggested that it is involved in information transmission in the respiratory organs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

507.93

Formula

C₂₅H₂₂ClN₅O₅

CAS No.
SMILES

O=C(N(C1=O)C[[email protected]](C)C(O)=O)N=C(NC2=CC=C(C=C2)OC3=CC=CC=N3)N1CC4=CC=C(C=C4)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: 98.64% ee.: 99.14%

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Keywords:

(E/Z)-SivopixantP2X ReceptorP2XRsP2X3respiratorydiseasescoughInhibitorinhibitorinhibit

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