2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. Sivopixant

Sivopixant  (Synonyms: S-600918)

Cat. No.: HY-137451 Purity: 98.64%
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Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect.

For research use only. We do not sell to patients.

Sivopixant Chemical Structure

Sivopixant Chemical Structure

CAS No. : 2414285-40-6

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Based on 1 publication(s) in Google Scholar

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Sivopixant Related Antibodies

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Description

Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect[1].

In Vivo

Sivopixant (S-600918) (i.v.;1 mg/kg) shows a longer half-life (T1/2= 10.1 hours) and a strong analgesic effect in the rat Seltzer model of allodynia (ED50=0.4 mg/kg)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

507.93

Formula

C25H22ClN5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=O)C[C@H](C)C(O)=O)N/C(N1CC2=CC=C(C=C2)Cl)=N\C3=CC=C(C=C3)OC4=CC=CC=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Sivopixant Related Classifications

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Keywords:

Sivopixant2414285-40-6S-600918S600918S 600918P2X ReceptorP2XRsselectiveanalgesicsciaticnerveligationpainInhibitorinhibitorinhibit

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