1. Membrane Transporter/Ion Channel
  2. P2X Receptor
  3. NF110

NF110 

Cat. No.: HY-108671
Handling Instructions

NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons.

For research use only. We do not sell to patients.

NF110 Chemical Structure

NF110 Chemical Structure

CAS No. : 111150-22-2

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Description

NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons[1].

IC50 & Target

Ki: 36 nM (P2X3 Receptor)

In Vitro

NF110 shows an activity in the human tumour cell line panel, with IC30 of 362.3 μM[2].
NF110 inhibits HMGA2-DNA interactions with an IC50 of 0.87 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NF110 shows potency at Endogenous P2X Receptors in Rat DRG Neurons, with a peak amplitude of 675 pA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1096.91

Formula

C₄₁H₂₈N₆Na₄O₁₇S₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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NF110
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