JNJ-47965567
Based on 6 publication(s) in Google Scholar
JNJ-47965567 is a centrally permeable, high-affinity, selective P2X7 antagonist, with pKis of 7.9 and 8.7 for human and rat P2X7, respectively. JNJ-47965567 can be used to probe the role of central P2X7 in rodent models of CNS pathophysiology.
For research use only. We do not sell to patients.
- Purity : 99.64%
- CAS No.: 1428327-31-4
- Formula: C28H32N4O2S
- Molecular Weight:488.64
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) JNJ-47965567
More- J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
- J Cereb Blood Flow Metab. 2023 Sep;43(9):1503-1518. [Abstract]
- J Neurochem. 2022 Dec;163(5):419-437. [Abstract]
- FASEB J. 2023 Jun;37(6):e22955. [Abstract]
- J Endocrinol Invest. 2025 Feb;48(2):317-332. [Abstract]
- Purinergic Signal. 2026 Mar 30;22(2):35. [Abstract]
All P2X Receptor Isoforms
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Biological Activity
Description
IC50 & Target
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P2X7 Receptor |
In Vitro
JNJ-47965567 exhibits high affinity for human and rat P2X7 in membrane preparations of 1321N1 cells[1].
JNJ-47965567 does not block IL-6 and TNF-α release under conditions (LPS and BZ-ATP)[1].
JNJ-47965567 attenuates IL-1β release with pIC50s of 6.7 ± 0.07 (human blood), 7.5 ± 0.07 (human monocytes) and 7.1 ± 0.1 (rat microglia), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
JNJ-47965567 (30 mg/kg) attenuates amphetamine-induced hyperactivity and exhibits modest, yet significant efficacy in the rat model of neuropathic pain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats[1]
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Dosage:30 mg/kg, 100 mg/kg
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Administration:Subcutaneous injection; 30 minutes prior to Bz-ATP infusion
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Result:Significantly attenuated IL-1β release at 100 mg/kg, with no effect at 30 mg/kg dose group.
Chemical Information
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CAS No. 1428327-31-4
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Appearance Solid
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Molecular Weight 488.64
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Formula C28H32N4O2S
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Color White to off-white
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SMILES
O=C(C1=CC=CN=C1SC2=CC=CC=C2)NCC3(N4CCN(C5=CC=CC=C5)CC4)CCOCC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage. [Abstract]2025 Aug 28;22(1):208. PMID: 40877894 -
J Cereb Blood Flow Metab
2023 Sep;43(9):1503-1518. PMID: 37194247 -
J Neurochem
Continued P2X7 activation leads to mitochondrial fission and compromising microglial phagocytosis after subarachnoid haemorrhage. [Abstract]2022 Dec;163(5):419-437. PMID: 36269673 -
FASEB J
P2X7 receptor of microglia in olfactory bulb mediates the pathogenesis of olfactory dysfunction in a mouse model of allergic rhinitis. [Abstract]2023 Jun;37(6):e22955. PMID: 37159387 -
J Endocrinol Invest
2025 Feb;48(2):317-332. PMID: 39527372 -
Purinergic Signal
P2X7 receptor-mediated cGAS-STING pathway activation underlies chronic stress-induced depressive-like behaviors. [Abstract]2026 Mar 30;22(2):35. PMID: 41912731
Purity & Documentation
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Data Sheet (294 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNJ-47965567 Related Classifications
HY-101418 Related Classifications
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