1. Anti-infection
    Cell Cycle/DNA Damage
  2. Bacterial
    DNA/RNA Synthesis
  3. Ibezapolstat

Ibezapolstat (Synonyms: ACX-362E; GLS-362E)

Cat. No.: HY-128357
Handling Instructions

Ibezapolstat (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat is developed for the research of C. difficile infection(CDI).

For research use only. We do not sell to patients.

Ibezapolstat Chemical Structure

Ibezapolstat Chemical Structure

CAS No. : 1275582-97-2

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Description

Ibezapolstat (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat is developed for the research of C. difficile infection(CDI)[1][2].

IC50 & Target

Ki: 0.325 μM (DNA pol IIIC from C. difficile)[2]

In Vitro

Ibezapolstat binds to and inhibits DNA pol IIIC from aerobic and low G+C Gram-positive bacteria[1].
Ibezapolstat displays antibacterial activities against broad spectrum of C. difficile pathogens, with an MIC range of 1-8 μg/mL for a panel of 104 clinical isolates of C. difficile overall in vitro[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ibezapolstat is poorly absorbed and apparently nontoxic in the hamster C. difficile-associated disease (CDAD) model (potential for achieving a high local concentration at the site of C. difficile infection in the colon)[3].
Ibezapolstat (50 mg/kg; p.o.; twice daily, for 3 days) shows strong anti-C. difficile properties in the hamster CDAD model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female golden Syrian hamsters (80-90-g), CDAD model[3]
Dosage: 50 mg/kg
Administration: Oral administration, twice daily, for 3 days
Result: Completely protected C. difficile-infected animals for a period of up to 5 days.
Molecular Weight

423.30

Formula

C₁₈H₂₀Cl₂N₆O₂

CAS No.

1275582-97-2

SMILES

O=C1NC(NCC2=CC=C(Cl)C(Cl)=C2)=NC3=C1N(CCN4CCOCC4)C=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

IbezapolstatACX-362E GLS-362EBacterialDNA/RNA SynthesisClostridiumdifficileinfectionCDIreplication-specificDNApolymeraseInhibitorinhibitorinhibit

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Ibezapolstat
Cat. No.:
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