Ibezapolstat hydrochloride
Based on 4 publication(s) in Google Scholar
Ibezapolstat hydrochloride is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat hydrochloride is developed for the research of C. difficile infection(CDI).
For research use only. We do not sell to patients.
- CAS No.: 1275582-98-3
- Formula: C18H21Cl3N6O2
- Molecular Weight:459.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Ibezapolstat hydrochloride
MoreAll DNA/RNA Synthesis Isoforms
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Biological Activity
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DNA Polymerase |
Chemical Information
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CAS No. 1275582-98-3
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Molecular Weight 459.76
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Formula C18H21Cl3N6O2
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SMILES
O=C1N=C(NCC2=CC=C(C(Cl)=C2)Cl)NC3=C1N(CCN4CCOCC4)C=N3.Cl
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Synonyms
ACX-362E hydrochloride; GLS-362E hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Expert Opin Investig Drugs
2025 Nov;34(11):869-885. PMID: 41117146 -
BMC Gastroenterol
In vitro susceptibility of clinical Clostridioides difficile isolates in Israel to metronidazole, vancomycin, fidaxomicin, ridinilazole and ibezapolstat. [Abstract]2025 Mar 31;25(1):209. PMID: 40165093 -
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Purity & Documentation
References
[1]. Beverly Murray, et al. In vitro activity of the novel antibacterial agent ibezapolstat (ACX-362E) against Clostridioides difficile. J Antimicrob Chemother. 2020 Aug 1;75(8):2149-2155. [Content Brief]
[2]. Andrea Torti, et al. Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds. Curr Enzym Inhib. 2011 Oct; 7(3): 147-153. [Content Brief]
[3]. Sofya Dvoskin, et al. A Novel Agent Effective against Clostridium difficile Infection. Antimicrob Agents Chemother. 2012 Mar; 56(3): 1624-1626. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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