Ibezapolstat hydrochloride
Based on 4 publication(s) in Google Scholar
Ibezapolstat hydrochloride is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat hydrochloride is developed for the research of C. difficile infection(CDI).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1275582-98-3
- Formel: C18H21Cl3N6O2
- Molecular Weight:459.76
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Ibezapolstat hydrochloride
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Biologische Aktivität
Beschreibung
IC50 & Target
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DNA Polymerase |
Chemical Information
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CAS. Nr. 1275582-98-3
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Molecular Weight 459.76
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Formel C18H21Cl3N6O2
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SMILES
O=C1N=C(NCC2=CC=C(C(Cl)=C2)Cl)NC3=C1N(CCN4CCOCC4)C=N3.Cl
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Synonyms
ACX-362E hydrochloride; GLS-362E hydrochloride
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Expert Opin Investig Drugs
2025 Nov;34(11):869-885. PMID: 41117146 -
BMC Gastroenterol
In vitro susceptibility of clinical Clostridioides difficile isolates in Israel to metronidazole, vancomycin, fidaxomicin, ridinilazole and ibezapolstat. [Abstract]2025 Mar 31;25(1):209. PMID: 40165093 -
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Reinheit & Dokumentation
Verweise
[1]. Beverly Murray, et al. In vitro activity of the novel antibacterial agent ibezapolstat (ACX-362E) against Clostridioides difficile. J Antimicrob Chemother. 2020 Aug 1;75(8):2149-2155. [Content Brief]
[2]. Andrea Torti, et al. Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds. Curr Enzym Inhib. 2011 Oct; 7(3): 147-153. [Content Brief]
[3]. Sofya Dvoskin, et al. A Novel Agent Effective against Clostridium difficile Infection. Antimicrob Agents Chemother. 2012 Mar; 56(3): 1624-1626. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Ibezapolstat hydrochloride Related Classifications
HY-128357A Related Classifications
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