1275582-98-3
1275582-98-3
Chemical Structure
Ibezapolstat hydrochloride
Synonym(s): ACX-362E hydrochloride; GLS-362E hydrochloride
- CAS. Nr.: 1275582-98-3
- Formula:C18H21Cl3N6O2
- Molecular Weight:459.76
InChIKey: RNBLTEKVVQGCIM-UHFFFAOYSA-N
SMILES: O=C1N=C(NCC2=CC=C(C(Cl)=C2)Cl)NC3=C1N(CCN4CCOCC4)C=N3.Cl
Biological Activity: Ibezapolstat hydrochloride is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat hydrochloride is developed for the research of C. difficile infection(CDI)[1][2].
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Ibezapolstat hydrochloride | Ibezapolstat hydrochloride is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat hydrochloride is developed for the research of C. difficile infection(CDI). | |||||||||||||||||||||
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References
- [1]. Beverly Murray, et al. In vitro activity of the novel antibacterial agent ibezapolstat (ACX-362E) against Clostridioides difficile. J Antimicrob Chemother. 2020 Aug 1;75(8):2149-2155. [Content Brief]
- [2]. Andrea Torti, et al. Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds. Curr Enzym Inhib. 2011 Oct; 7(3): 147-153. [Content Brief]
