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Results for "

Aryl Hydrocarbon Receptor (AhR)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aryl Hydrocarbon Receptor (115) 5-HT Receptor (1) Adenosine Receptor (3) Akt (1) Androgen Receptor (3) Apoptosis (16) Autophagy (2) Biochemical Assay Reagents (3) Caspase (2) CDK (2) Checkpoint Kinase (Chk) (1) Collagen (3) Cytochrome P450 (21) DNA/RNA Synthesis (3) Drug Intermediate (3) Drug Metabolite (6) E1/E2/E3 Enzyme (2) Endogenous Metabolite (16) Environmental Pollutants (6) Epigenetic Reader Domain (1) ERK (3) Estrogen Receptor/ERR (5) Ferroptosis (2) Fungal (3) GLUT (2) Glycosidase (2) GSK-3 (2) HBV (1) Integrin (3) Interleukin Related (7) Isotope-Labeled Compounds (11) LXR (1) MDM-2/p53 (4) MEK (2) Na+/K+ ATPase (1) NF-κB (3) p38 MAPK (3) PPAR (1) Prostaglandin Receptor (1) PROTACs (1) Pyroptosis (2) Reactive Oxygen Species (ROS) (2) Reference Standards (27) TGF-beta/Smad (1) UGT (3) VD/VDR (2) VEGFR (1) β-glucuronidase (1)
By Research Areas:	Cancer (65) Cardiovascular Disease (2) Endocrinology (6) Infection (5) Inflammation/Immunology (36) Metabolic Disease (10) Neurological Disease (14)
Click Chemistry:	Alkynes (1)

126

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

GMP Molecules

Targets Recommended: Aryl Hydrocarbon Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12684

CH-223191 110+ Cited Publications	Aryl Hydrocarbon Receptor	Cancer
CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC₅₀ of 0.03 μM .

HY-15001

Stemregenin 1 15+ Cited Publications SR1	Aryl Hydrocarbon Receptor	Cancer
Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC₅₀ of 127 nM.

HY-109044

Tapinarof 10+ Cited Publications WBI-1001; Benvitimod; GSK2894512	Aryl Hydrocarbon Receptor	Inflammation/Immunology
Tapinarof (WBI-1001) is a natural **aryl hydrocarbon receptor** (AhR) agonist with an EC₅₀ of 13 nM. Tapinarof resolves skin inflammation in mice .

HY-15484

Pifithrin-α hydrobromide 95+ Cited Publications Pifithrin hydrobromide; PFTα hydrobromide	MDM-2/p53 Aryl Hydrocarbon Receptor Ferroptosis Apoptosis	Cancer
Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an **aryl hydrocarbon receptor (AhR)** agonist.

HY-12028

PD98059 Maximum Cited Publications 391 Publications Verification	MEK ERK Aryl Hydrocarbon Receptor Autophagy	Cancer
PD98059 is a potent and selective MEK inhibitor with an IC₅₀ of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC₅₀ of 2-7 µM) and MEK2 (IC₅₀ of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the **aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC₅₀ of 4 μM) and AHR transformation (IC₅₀** of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy .

HY-N0178

Diosmin Maximum Cited Publications 17 Publications Verification	Aryl Hydrocarbon Receptor	Cardiovascular Disease Cancer
Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the **aryl hydrocarbon receptor** (AhR).

HY-12451

FICZ 25+ Cited Publications 6-Formylindolo[3,2-b]carbazole	Aryl Hydrocarbon Receptor	Others
FICZ is a potent **aryl hydrocarbon receptor (AhR) agonist with a K_d** of 70 pM.

HY-B0311

Carbidopa 2 Publications Verification (S)-(-)-Carbidopa	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa ((S)-(-)-Carbidopa), a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective **aryl hydrocarbon receptor (AhR)** modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .

HY-135829

BAY 2416964 1 Publications Verification	Aryl Hydrocarbon Receptor	Cancer
BAY 2416964 is a potent and orally active **aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC₅₀** of 341 nM. BAY 2416964 has the potential for solid tumors treatment .

HY-N0170

Indole-3-carbinol 15+ Cited Publications Indole-3-methanol	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite	Cancer
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an **Aryl hydrocarbon receptor** (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-W014502

D-Kynurenine	Aryl Hydrocarbon Receptor Endogenous Metabolite	Cancer
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating **aryl hydrocarbon receptor (AHR)** .

HY-W011910

Potassium 1H-indol-3-yl sulfate 1 Publications Verification	Endogenous Metabolite Aryl Hydrocarbon Receptor Cytochrome P450 UGT Interleukin Related	Metabolic Disease
Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases .

HY-102023

GNF351 5+ Cited Publications	Aryl Hydrocarbon Receptor	Others
GNF351 is a full **aryl hydrocarbon receptor (AHR)** antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC₅₀ of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes .

HY-141609

IK-175 AHR antagonist 5 free base	Aryl Hydrocarbon Receptor	Cancer
IK-175 is a selective and orally active **aryl hydrocarbon receptor (AHR)** inhibitor. IK-175 effectively blocks AHR from translocating from the cytoplasm to the nucleus. IK-175 is highly selective for AHR over other receptors, transporters, and kinases .

HY-114740

β-Naphthoflavone 1 Publications Verification 5,6-Benzoflavone; beta-NF	Aryl Hydrocarbon Receptor Apoptosis	Neurological Disease Cancer
β-Naphthoflavone is an exogenous aryl hydrocarbon receptor (AHR) ligand. β-Naphthoflavone can activate AHR to participate in various biological processes, including cell growth, differentiation, apoptosis, and metabolism. β-Naphthoflavone has antioxidant activity and can exert its antioxidant function by regulating the activity of antioxidant enzymes. β-Naphthoflavone is also a non-carcinogenic CYP1A inducer and can be used to study aristolochic acid (AAI) induced renal injury .

HY-19317

ITE 5+ Cited Publications	Aryl Hydrocarbon Receptor	Inflammation/Immunology Cancer
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to *AHR, with a K_i* of 3 nM. ITE also has immunosuppressive activity.

HY-B0845

Prochloraz 1 Publications Verification BTS 40542	Environmental Pollutants Estrogen Receptor/ERR Aryl Hydrocarbon Receptor Fungal Androgen Receptor	Infection Endocrinology
Prochloraz is an imidazole antifungal. Prochloraz is as an *estrogen receptor* (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC₅₀ values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC₅₀** of 1 μM .

HY-W007355

Skatole 5+ Cited Publications 3-Methylindole; 3-Methyl-1H-indole	Environmental Pollutants Apoptosis Endogenous Metabolite p38 MAPK Aryl Hydrocarbon Receptor	Others
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .

HY-W011338

Benzyl butyl phthalate 1 Publications Verification	Environmental Pollutants Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates **aryl hydrocarbon receptor (AhR)** in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-111449

BAY-218 2 Publications Verification AHR antagonist 1	Aryl Hydrocarbon Receptor	Inflammation/Immunology Cancer
BAY-218 (AHR antagonist 1) is an **aryl hydrocarbon receptor (AHR)** antagonist. BAY-218 has AHR inhibitory activity with an IC₅₀ of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses .

HY-B0311A

Carbidopa monohydrate 2 Publications Verification (S)-(-)-Carbidopa monohydrate	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective **aryl hydrocarbon receptor (AhR)** modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

HY-18619

YL-109 2 Publications Verification	Aryl Hydrocarbon Receptor	Cancer
YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through **aryl hydrocarbon receptor (AhR)** signaling. YL-109 has ability to inhibit breast cancer cell growth and invasiveness .

HY-15001G

Stemregenin 1 SR1	Aryl Hydrocarbon Receptor	Cancer
Stemregenin 1 (SR1) (GMP) is a GMP-grade Stemregenin 1 (HY-15001). GMP-grade small molecules can be used as adjuvants in cell therapy. Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with an IC₅₀ of 127 nM. Stemregenin 1 (GMP) can competitively bind to AhR and inhibit its nuclear translocation, inhibiting osteoclastogenesis and promoting hematopoietic progenitor cell expansion by blocking the AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway. Stemregenin 1 (GMP) can be used for the study of osteoporosis, in vitro expansion of hematopoietic stem cells, and the study of the mechanism of bone metabolic diseases .

HY-D0932

Sudan IV Solvent Red 24; C.I. 26105	Environmental Pollutants Biochemical Assay Reagents Cytochrome P450 Aryl Hydrocarbon Receptor	Metabolic Disease
Sudan IV is an agonist of the **aryl hydrocarbon receptor** (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections .

HY-103221

MeBIO	Aryl Hydrocarbon Receptor GSK-3 CDK	Others
MeBIO is a potent *AhR* (aryl hydrocarbon receptor) agonist, with IC₅₀ of 44 μM (GSK-3) and 55 μM (CDK1/cyclin B), respectively .

HY-N0586

Norisoboldine (+)-Laurelliptine	Adenosine Receptor	Inflammation/Immunology
Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

HY-W014075

1-Hydroxypyrene	Aryl Hydrocarbon Receptor Cytochrome P450 Collagen	Inflammation/Immunology
1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for **aryl hydrocarbon receptor** (AhR) and can lead to renal fibrosis .

HY-112629

PDM2 3 Publications Verification	Aryl Hydrocarbon Receptor	Inflammation/Immunology
PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an K_i of 1.2±0.4 nM.

HY-N0178R

Diosmin (Standard)	Reference Standards Aryl Hydrocarbon Receptor	Cardiovascular Disease Cancer
Diosmin (Standard) is the analytical standard of Diosmin. This product is intended for research and analytical applications. Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).

HY-135750

VAF347 3 Publications Verification	Aryl Hydrocarbon Receptor	Inflammation/Immunology
VAF347 is a cell permeable and highly affinity **aryl hydrocarbon receptor (AhR) agonist and induces AhR** signaling. VAF347 inhibits the development of CD14 ⁺CD11b ⁺ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects .

HY-124421

5F-203 NSC-703786	Aryl Hydrocarbon Receptor	Others
5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38 .

HY-N4095

Brevifolincarboxylic acid	Aryl Hydrocarbon Receptor Glycosidase Reactive Oxygen Species (ROS) GLUT	Metabolic Disease Inflammation/Immunology Cancer
Brevifolincarboxylic acid is a phenolic compound. Brevifolincarboxylic acid can be isolated from Duchesnea chrysantha. Brevifolincarboxylic acid inhibits α-glucosidase with an IC₅₀ value of 323.46 μM. Brevifolincarboxylic acid has an inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarbacid scavenges ROS. Brevifolincarbacid restores the glucose uptake activity of myotubes. Brevifolincarboxylic acid has antitumor activity against lung and gastric cancer. Brevifolincarbacid can be used in the study of diabetes and inflammatory diseases .

HY-111441

1,4-Chrysenequinone Chrysene-1,4-dione	Aryl Hydrocarbon Receptor	Cancer
1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).

HY-103220

6,2',4'-Trimethoxyflavone 1 Publications Verification	Aryl Hydrocarbon Receptor	Neurological Disease Cancer
6,2',4'-Trimethoxyflavone is a potent **aryl hydrocarbon receptor (AHR)** antagonist. 6,2',4'-Trimethoxyflavone represses AHR-mediated gene induction .

HY-135831

AHR antagonist 2 1 Publications Verification	Aryl Hydrocarbon Receptor	Inflammation/Immunology Cancer
AHR antagonist 2 (Example 1) is a potent aryl hydrocarbon receptor (AHR) antagonist with IC₅₀s of 885 pM and 2.03 nM for human and mouse AHR. AHR antagonist 2 can be used for the studies of cancers and imbalance of the immune response .

HY-144339

AhR agonist 2 1 Publications Verification	Aryl Hydrocarbon Receptor	Others
AhR agonist 2 (Compound 12a) is a potent agonist of aryl hydrocarbon receptor (AhR) with an EC₅₀ of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers the transcription of downstream genes and promote skin barrier repair. AhR agonist 2 has the potential for the research of psoriasis .

HY-103222

DiMNF 3',4'-Dimethoxy-αNF	Aryl Hydrocarbon Receptor	Inflammation/Immunology
DiMNF (3',4'-Dimethoxy-αNF) is a selective **aryl hydrocarbon receptor (AHR)** modulator. DiMNF is a competitive AHR ligand (IC₅₀ = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent .

HY-N0586A

Norisoboldine hydrochloride (+)-Laurelliptine hydrochloride	Adenosine Receptor	Inflammation/Immunology
Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

HY-W014701

1,4-Dihydroxy-2-naphthoic acid	Aryl Hydrocarbon Receptor Cytochrome P450 Apoptosis Interleukin Related	Neurological Disease Inflammation/Immunology Endocrinology
1,4-Dihydroxy-2-naphthoic acid is an aryl hydrocarbon receptor (AhR) agonist. 1,4-Dihydroxy-2-naphthoic acid is also a bacterially derived metabolite and has anti-inflammatory activity .

HY-130256

β-NF-JQ1	PROTACs Epigenetic Reader Domain	Cancer
β-NF-JQ1 is a PROTAC that recruits **Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD)** proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity .

HY-W014075S

1-Hydroxypyrene-d9	Isotope-Labeled Compounds Aryl Hydrocarbon Receptor Cytochrome P450 Collagen	Inflammation/Immunology
1-Hydroxypyrene-d₉ is the deuterium labeled 1-Hydroxypyrene (HY-W014075). 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for **aryl hydrocarbon receptor** (AhR) and can lead to renal fibrosis .

HY-117102

ANI-7	Aryl Hydrocarbon Receptor Checkpoint Kinase (Chk)	Cancer
ANI-7 is an activator of **aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF-7 breast cancer cells with a GI₅₀ of 0.56 μM. ANI-7 induces CYP1-metabolizing mono-oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2)** activation, S-phase cell cycle arrest, and cell death in sensitive breast cancer cell lines .

HY-77278

25-Hydroxytachysterol3	VD/VDR Aryl Hydrocarbon Receptor LXR PPAR	Others
25-Hydroxytachysterol3 is the metabolite of Vitamin D3 (HY-15398). 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitamin D receptor (VDR) and aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1 .

HY-112628

CAY10464 AHR antagonist 7	Aryl Hydrocarbon Receptor	Cancer
CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a K_i of 1.4 nM .

HY-154825

20-Hydroxyvitamin D3 20(OH)D3; 20S-Hydroxyvitamin D3	VD/VDR Aryl Hydrocarbon Receptor NF-κB Cytochrome P450	Inflammation/Immunology Cancer
20-Hydroxyvitamin D3 (20(OH)D3), a product of vitamin D3 hydroxylation, is a noncalcemic immunomodulator. 20-Hydroxyvitamin D3 binds to vitamin D receptor (VDR), activates VDR and aryl hydrocarbon receptor (AhR) signaling, stimulates CYP24A1 expression, and drives VDR nuclear translocation. 20-Hydroxyvitamin D3 inhibits NF-κB activity via IκBα upregulation. 20-Hydroxyvitamin D3 acts as a substrate for CYP27B1 and rat CYP24A1, undergoing hydroxylation to form dihydroxy-derivatives. 20-Hydroxyvitamin D3 inhibits cell proliferation, colony formation, migration, and tumor growth, and induces cell differentiation in cancer cells. 20-Hydroxyvitamin D3 can be used for the research of inflammatory and autoimmune diseases, melanoma, breast carcinomas, and hepatocarcinoma .

HY-175785

X15695	Estrogen Receptor/ERR Aryl Hydrocarbon Receptor Apoptosis MDM-2/p53	Cancer
X15695 is selective and orally active estrogen receptor (ERα) degrader. X15695 is an aryl hydrocarbon receptor (AHR) ligand. X15695 enables AHR to form a complex with the ERα, promoting its proteasomal degradation. X15695 inhibits the breast cancer cells proliferation, promotes cell cycle block and induces apoptosis. X15695 can be used for the study of breast cancer .

HY-N0170R

Indole-3-carbinol (Standard) Indole-3-methanol (Standard)	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite Reference Standards	Cancer
Indole-3-carbinol (Standard) is the analytical standard of Indole-3-carbinol. This product is intended for research and analytical applications. Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-W764758

3-OH-Kynurenamine dihydroiodide	Aryl Hydrocarbon Receptor	Inflammation/Immunology
3-OH-Kynurenamine dihydroiodide is the dihydroiodide form of 3-OH-Kynurenamine (HY-156908). 3-OH-Kynurenamine dihydroiodide is an activator for aryl hydrocarbon receptor (AhR), and thus regulates the immune response. 3-OH-Kynurenamine dihydroiodide upregulates the expressions of Ido1 and Tgfb1, ameliorates the skin inflammation in psoriasis mouse model and kidney damage in nephrotoxic lupus mouse model .

HY-W007355R

Skatole (Standard) 3-Methylindole (Standard); 3-Methyl-1H-indole (Standard)	Reference Standards Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Apoptosis	Others
Skatole (Standard) is the analytical standard of Skatole. This product is intended for research and analytical applications. Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .

HY-136220

AHR antagonist 5	Aryl Hydrocarbon Receptor	Cancer
AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor *(AHR)* antagonist extracted from patent WO2018195397, example 39, has an IC₅₀ of < 0.5 μΜ. AHR antagonist 5 significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1 .

Cat. No.	Product Name	Type

HY-15001G

Stemregenin 1

SR1

Fluorescent Dyes

Stemregenin 1 (SR1) (GMP) is a GMP-grade Stemregenin 1 (HY-15001). GMP-grade small molecules can be used as adjuvants in cell therapy. Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with an IC₅₀ of 127 nM. Stemregenin 1 (GMP) can competitively bind to AhR and inhibit its nuclear translocation, inhibiting osteoclastogenesis and promoting hematopoietic progenitor cell expansion by blocking the AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway. Stemregenin 1 (GMP) can be used for the study of osteoporosis, in vitro expansion of hematopoietic stem cells, and the study of the mechanism of bone metabolic diseases .

HY-D0932

Sudan IV

Solvent Red 24; C.I. 26105

Fluorescent Dyes

Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections .

HY-D0932R

Sudan IV (Standard)

Solvent Red 24 (Standard); C.I. 26105 (Standard)

Fluorescent Dyes

Sudan IV (Standard) (Solvent Red 24 (Standard)) is the analytical standard of Sudan IV (HY-D0932). This product is intended for research and analytical applications. Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections.

Cat. No.	Product Name	Type

HY-15001G

Stemregenin 1

SR1

Biochemical Assay Reagents

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0178

Diosmin Maximum Cited Publications 17 Publications Verification	Cardiovascular Disease Flavonoids Classification of Application Fields Flavones Rutaceae Plants Citrus Disease Research Fields Source Classification	Aryl Hydrocarbon Receptor
Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the **aryl hydrocarbon receptor** (AhR).

HY-B2132

Tryptamine 1 Publications Verification 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine	Alkaloids Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite 5-HT Receptor Aryl Hydrocarbon Receptor
Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models .

HY-N0170

Indole-3-carbinol 15+ Cited Publications Indole-3-methanol	Alkaloids other families Classification of Application Fields Plants Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification Cancer	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite
Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an **Aryl hydrocarbon receptor** (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-W014502

D-Kynurenine	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer	Aryl Hydrocarbon Receptor Endogenous Metabolite
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating **aryl hydrocarbon receptor (AHR)** .

HY-W011910

Potassium 1H-indol-3-yl sulfate 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Aryl Hydrocarbon Receptor Cytochrome P450 UGT Interleukin Related
Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases .

HY-W007355

Skatole 5+ Cited Publications 3-Methylindole; 3-Methyl-1H-indole	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Apoptosis Endogenous Metabolite p38 MAPK Aryl Hydrocarbon Receptor
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .

HY-W017113

2-Mercaptobenzothiazole 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR) , inhibiting thyroid hormone synthesis and dopamine beta-hydroxylase activity . 2-Mercaptobenzothiazole promotes bladder cancer cell invasion by altering the conformation of the AhR ligand binding domain (LBD), activating AhR transcription, and upregulating the mRNA and protein expression of target genes CYP1A1 and CYP1B1 . 2-Mercaptobenzothiazole inhibits thyroid peroxidase (TPO) with an IC₅₀ value of 11.5 μM, induces histological changes such as follicular cell hypertrophy in Xenopus laevis tadpoles, delaying metamorphosis . 2-Mercaptobenzothiazole increases chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, and enhances carcinogenicity in F344/N rats . 2-Mercaptobenzothiazole inhibits norepinephrine synthesis in mice and completely blocks the conversion of exogenous dopamine to norepinephrine in rat cardiomyocytes .

HY-N0586

Norisoboldine (+)-Laurelliptine	Alkaloids Classification of Application Fields Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm. Inflammation/Immunology Disease Research Fields Source Classification	Adenosine Receptor
Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

HY-W014075

1-Hydroxypyrene	Structural Classification Natural Products Monophenols Classification of Application Fields Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Aryl Hydrocarbon Receptor Cytochrome P450 Collagen
1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for **aryl hydrocarbon receptor** (AhR) and can lead to renal fibrosis .

HY-N0178R

Diosmin (Standard)	Structural Classification Flavonoids Flavones Rutaceae Plants Citrus Source Classification	Reference Standards Aryl Hydrocarbon Receptor
Diosmin (Standard) is the analytical standard of Diosmin. This product is intended for research and analytical applications. Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).

HY-N4095

Brevifolincarboxylic acid	Structural Classification Natural Products Classification of Application Fields Polygonaceae Metabolic Disease Plants other families Phenols Polyphenols Polygonum capitatum Buch.-Ham. ex D. Don Prodr Inflammation/Immunology Disease Research Fields Source Classification	Aryl Hydrocarbon Receptor Glycosidase Reactive Oxygen Species (ROS) GLUT
Brevifolincarboxylic acid is a phenolic compound. Brevifolincarboxylic acid can be isolated from Duchesnea chrysantha. Brevifolincarboxylic acid inhibits α-glucosidase with an IC₅₀ value of 323.46 μM. Brevifolincarboxylic acid has an inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarbacid scavenges ROS. Brevifolincarbacid restores the glucose uptake activity of myotubes. Brevifolincarboxylic acid has antitumor activity against lung and gastric cancer. Brevifolincarbacid can be used in the study of diabetes and inflammatory diseases .

HY-N0586A

Norisoboldine hydrochloride (+)-Laurelliptine hydrochloride	Alkaloids Structural Classification Classification of Application Fields Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm. Inflammation/Immunology Disease Research Fields Source Classification	Adenosine Receptor
Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

HY-W014701

1,4-Dihydroxy-2-naphthoic acid	Ketones, Aldehydes, Acids Source Classification	Aryl Hydrocarbon Receptor Cytochrome P450 Apoptosis Interleukin Related
1,4-Dihydroxy-2-naphthoic acid is an aryl hydrocarbon receptor (AhR) agonist. 1,4-Dihydroxy-2-naphthoic acid is also a bacterially derived metabolite and has anti-inflammatory activity .

HY-N0170R

Indole-3-carbinol (Standard) Indole-3-methanol (Standard)	Alkaloids Structural Classification other families Plants Endogenous metabolite Indole Alkaloids Source Classification	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite Reference Standards
Indole-3-carbinol (Standard) is the analytical standard of Indole-3-carbinol. This product is intended for research and analytical applications. Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-W007355R

Skatole (Standard) 3-Methylindole (Standard); 3-Methyl-1H-indole (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Aryl Hydrocarbon Receptor p38 MAPK Endogenous Metabolite Apoptosis
Skatole (Standard) is the analytical standard of Skatole. This product is intended for research and analytical applications. Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .

HY-104026B

L-Kynurenine sulfate	Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite Aryl Hydrocarbon Receptor
L-Kynurenine sulfate, an **aryl hydrocarbon receptor** (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-129247

Versicolorin A	Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Other Diseases Disease Research Fields Source Classification	MDM-2/p53 Aryl Hydrocarbon Receptor Cytochrome P450
Versicolorin A is a biosynthetic precursor of Aflatoxin B1 (HY-N6615). Versicolorin A induces phosphorylation of p53. Versicolorin A activates the aryl hydrocarbon receptor *AhR* and significantly induces the expression of CYP1A1. Versicolorin A exerts genotoxic and cytotoxic effects. Versicolorin A enhances the genotoxicity of aflatoxin B1 in cells by promoting CYP450-mediated bioactivation of aflatoxin B1. Versicolorin A can be used in research related to colorectal cancer and hepatocellular carcinoma .

HY-N0586R

Norisoboldine (Standard) (+)-Laurelliptine (Standard)	Alkaloids Structural Classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm. Source Classification	Reference Standards Adenosine Receptor
Norisoboldine (Standard) is the analytical standard of Norisoboldine. This product is intended for research and analytical applications. Norisoboldine is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis .

HY-W014502R

D-Kynurenine (Standard)	Ketones, Aldehydes, Acids Endogenous metabolite	Reference Standards Aryl Hydrocarbon Receptor Endogenous Metabolite
D-Kynurenine (Standard) is the analytical standard of D-Kynurenine. This product is intended for research and analytical applications. D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating **aryl hydrocarbon receptor (AHR)** .

HY-N2998R

Ganoderenic acid A (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Terpenoids Plants Endogenous metabolite Source Classification	Reference Standards β-glucuronidase
Carbidopa (monohydrate) (Standard) is the analytical standard of Carbidopa (monohydrate). This product is intended for research and analytical applications. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

HY-W014075R

1-Hydroxypyrene (Standard)	Structural Classification Natural Products Monophenols Phenols Endogenous metabolite Source Classification	Reference Standards Aryl Hydrocarbon Receptor Cytochrome P450 Collagen
1-Hydroxypyrene (Standard) is the analytical standard of 1-Hydroxypyrene (HY-W014075). This product is intended for research and analytical applications. 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for **aryl hydrocarbon receptor** (AhR) and can lead to renal fibrosis.

HY-N4095R

Brevifolincarboxylic acid (Standard)	Structural Classification Natural Products other families Polygonaceae Phenols Polyphenols Plants Polygonum capitatum Buch.-Ham. ex D. Don Prodr Source Classification	Reference Standards Aryl Hydrocarbon Receptor Glycosidase Reactive Oxygen Species (ROS) GLUT
Brevifolincarboxylic acid (Standard) is the analytical standard of Brevifolincarboxylic acid (HY-N4095). This product is intended for research and analytical applications. Brevifolincarboxylic acid is a phenolic compound. Brevifolincarboxylic acid can be isolated from Duchesnea chrysantha. Brevifolincarboxylic acid inhibits α-glucosidase with an IC₅₀ value of 323.46 μM. Brevifolincarboxylic acid has an inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarbacid scavenges ROS. Brevifolincarbacid restores the glucose uptake activity of myotubes. Brevifolincarboxylic acid has antitumor activity against lung and gastric cancer. Brevifolincarbacid can be used in the study of diabetes and inflammatory diseases .

HY-W014701R

1,4-Dihydroxy-2-naphthoic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Reference Standards Aryl Hydrocarbon Receptor Cytochrome P450 Apoptosis Interleukin Related
1,4-Dihydroxy-2-naphthoic acid (Standard) is the analytical standard for 1,4-Dihydroxy-2-naphthoic acid (HY-W014701). 1,4-Dihydroxy-2-naphthoic acid is an orally active aryl hydrocarbon receptor (AhR) agonist and a bifidogenic growth stimulator. 1,4-Dihydroxy-2-naphthoic acid can improve the motor dysfunction in parkinson's disease (PD) model through *AhR*-dependent and -independent pathways. 1,4-Dihydroxy-2-naphthoic acid exerts anti-inflammatory effects by regulating the gut microbiota (such as promoting the proliferation of Bifidobacterium) and directly regulating the host immune system. 1,4-Dihydroxy-2-naphthoic acid induces apoptosis through G0/G1 cell cycle arrest in human keratinocyte to inhibit psoriasis .

HY-W011910R

Potassium 1H-indol-3-yl sulfate (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards Aryl Hydrocarbon Receptor Cytochrome P450 UGT Interleukin Related
Potassium 1H-indol-3-yl sulfate (Standard) is the analytical standard of Potassium 1H-indol-3-yl sulfate (HY-W011910). This product is intended for research and analytical applications. Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases.

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704187

	AHR Protein, Human (His) Aryl Hydrocarbon Receptor; Ah Receptor; lass E basic helix-loop-helix protein 76 (bHLHe76); AHR; BHLHE76	Human	E. coli
	AHR Protein, Human (His) is the recombinant human-derived AHR protein, expressed by E. coli, with N-10*His tag.

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Cat. No.	Product Name	Chemical Structure

HY-W011338S

Benzyl butyl phthalate-d4

Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate . Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-132429S

Potassium 1H-indol-3-yl sulfate-d5

Potassium 1H-indol-3-yl sulfate-d₅ is the deuterium labeled 3-Indoxyl Sulfate potassium. Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases.

HY-W014075S

1-Hydroxypyrene-d9
1-Hydroxypyrene-d₉ is the deuterium labeled 1-Hydroxypyrene (HY-W014075). 1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for **aryl hydrocarbon receptor** (AhR) and can lead to renal fibrosis .

HY-W011910S

Potassium 1H-indol-3-yl sulfate-d4

Potassium 1H-indol-3-yl sulfate-d₄ potassium is the deuterium labeled Potassium 1H-indol-3-yl sulfate. Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases.

HY-B0311AS

Carbidopa-d3 monohydrate
Carbidopa-d₃ (monohydrate) is the deuterium labeled Carbidopa monohydrate. Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth .

HY-104026CS

L-Kynurenine-13C10 sulfate hemihydrate
L-Kynurenine- ¹³C10 (sulfate hemihydrate) is the ¹³C labeled L-Kynurenine sulfate. L-Kynurenine sulfate hemihydrate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-104026BS

L-Kynurenine-13C10 sulfate
L-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-133677S

Mono(2-ethyl-5-hydroxyhexyl) phthalate-d4

Mono(2-ethyl-5-hydroxyhexyl) phthalate-d₄ (MEHHP-d₄) is a deuterium labeled Mono(2-ethyl-5-hydroxyhexyl) phthalate (HY-133677). Mono (2-ethyl-5-hydroxyhexyl) phthalate is a biomarker for human exposure to DEHP (HY-B1945). By activating the tryptophan-kynurenine-aryl hydrocarbon receptor (AhR) pathway, mono (2-ethyl-5-hydroxyhexyl) phthalate significantly increases the viability of primary uterine leiomyoma cells and reduces cell apoptosis. Mono (2-ethyl-5-hydroxyhexyl) phthalate correlates with decreased sperm DNA damage. Mono (2-ethyl-5-hydroxyhexyl) phthalate can be used in studies related to uterine leiomyoma.

HY-109044S

Tapinarof-d5
Tapinarof-d₅ (WBI-1001-d₅) is deuterium labeled Tapinarof. Tapinarof (WBI-1001) is a natural **aryl hydrocarbon receptor** (AhR) agonist with an EC₅₀ of 13 nM. Tapinarof resolves skin inflammation in mice .

HY-B0311S1

Carbidopa-d3-1
Carbidopa-d3-1 is the deuterium labeled Carbidopa (HY-B0311). Carbidopa, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa is a selective **aryl hydrocarbon receptor (AhR)** modulator. Carbidopa inhibits pancreatic cancer cell and tumor growth .

HY-W716464

Prochloraz-d7

Prochloraz-d₇ (BTS 40542-d₇) is the deuterium labeled Prochloraz (HY-B0845). Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC₅₀ values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC₅₀ of 1 μM .

HY-D0932S

Sudan IV-d6

Sudan IV-d₆ (Solvent Red 24-d₆) is the deuterium labeled Sudan IV(HY-D0932). Sudan IV is an agonist of the aryl hydrocarbon receptor (AhR) that activates downstream signaling pathways and induces CYP1A1 expression. Sudan IV promotes CYP1A1 gene transcription by activating AhR-ARNT heterodimers and binding to exogenous response elements (XREs) on DNA, thereby enhancing drug metabolizing enzyme activity. Sudan IV can be used to study the toxicity mechanisms of industrial dyes and the effects of interactions with serum proteins (such as bovine serum albumin (BSA)) on their distribution in vivo. Sudan IV is a fat-soluble diazo dye that can be used to stain lipids, triglycerides, and lipoproteins on frozen sections .

HY-G0007S

Omeprazole sulfone-d3

Omeprazole sulfone-d₃ is the deuterium labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

HY-G0007S1

Omeprazole sulfone-13C,d3

Omeprazole sulfone- ¹³C,d₃ is the deuterium and ¹³C labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .

HY-W007355S2

Skatole-13C6

Skatole- ¹³C₆ is the ¹³C-labeled Skatole (HY-W007355). Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream.

Host:	Mouse (1) Rabbit (3)
Reactivity:	Human (3) human (1)
Application:	ICC/IF (1) IP (1) WB (4) ELISA (1)
Isotype:	IgG (3) IgG2a (1)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80378

	Aryl Hydrocarbon Receptor Antibody (YA610) 1 Publications Verification Ah Receptor; Aromatic Hydrocarbon Receptor; Aryl Hydrocarbon Receptor; Aryl Hydrocarbon Receptor precursor; BHLHE76; Class E basic helix loop helix protein 76; HGNC:348; AHR_HUMAN.	WB, ICC/IF	Human
	Aryl Hydrocarbon Receptor Antibody (YA610) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aryl Hydrocarbon Receptor.

HY-P82417

	Aryl Hydrocarbon Receptor Antibody (YA2162) Ah Receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76; AHR	WB	Human
	Aryl Hydrocarbon Receptor Antibody (YA2162) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aryl Hydrocarbon Receptor.

HY-P82417A

	Aryl Hydrocarbon Receptor Antibody (YA2162)(PBS only) Ah Receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76; AHR	WB	Human
	Aryl Hydrocarbon Receptor Antibody (YA2162) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aryl Hydrocarbon Receptor.

HY-P810023

	AHRR Antibody (YA9367) BHLHE77, KIAA1234, AHRR, Aryl Hydrocarbon Receptor repressor, AhR repressor, AhRR, Class E basic helix-loop-helix protein 77, bHLHe77	WB, IP, ELISA	human
	AHRR Antibody (YA9367) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AHRR.

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Cat. No.	Product Name		Classification

HY-155505

AHR agonist 4		Alkynes
AHR agonist 4 (compound 24e) is an agonist of **Aryl hydrocarbon receptor** (AHR), assocaited with the immune balance of Th17/22 and Treg cells. AHR agonist 4 serves as a lead compound for anti-psoriasis drug, alleviates imiquimod (IMQ)-induced psoriasis-like skin lesion . AHR agonist 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Targets Recommended: Aryl Hydrocarbon Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15001G

Stemregenin 1 SR1	Aryl Hydrocarbon Receptor	Cancer
Stemregenin 1 (SR1) (GMP) is a GMP-grade Stemregenin 1 (HY-15001). GMP-grade small molecules can be used as adjuvants in cell therapy. Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with an IC₅₀ of 127 nM. Stemregenin 1 (GMP) can competitively bind to AhR and inhibit its nuclear translocation, inhibiting osteoclastogenesis and promoting hematopoietic progenitor cell expansion by blocking the AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway. Stemregenin 1 (GMP) can be used for the study of osteoporosis, in vitro expansion of hematopoietic stem cells, and the study of the mechanism of bone metabolic diseases .

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