CAY10464
Based on 1 Customer Validation
CAY10464 (AHR antagonist 7; compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a Ki of 1.4 nM.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 688348-37-0
- Formula: C15H12Cl2O
- Molecular Weight:279.16
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
In HepG2 cells, CAY10464 (100 nM) inhibits CYP1A1 mRNA expression, and reverses the suppressive effect of Benzo[a]pyrene on apolipoprotein A-I (apo A-I) gene expression[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 688348-37-0
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Appearance Solid
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Molecular Weight 279.16
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Formula C15H12Cl2O
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Color White to off-white
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SMILES
ClC1=CC(Cl)=CC(/C=C/C2=CC=C(OC)C=C2)=C1
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Synonyms
AHR antagonist 7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (358.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Philippe de Medina, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. [Content Brief]
[2]. Emad Naem,et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5822 mL | 17.9109 mL | 35.8218 mL | 89.5544 mL |
| 5 mM | 0.7164 mL | 3.5822 mL | 7.1644 mL | 17.9109 mL | |
| 10 mM | 0.3582 mL | 1.7911 mL | 3.5822 mL | 8.9554 mL | |
| 15 mM | 0.2388 mL | 1.1941 mL | 2.3881 mL | 5.9703 mL | |
| 20 mM | 0.1791 mL | 0.8955 mL | 1.7911 mL | 4.4777 mL | |
| 25 mM | 0.1433 mL | 0.7164 mL | 1.4329 mL | 3.5822 mL | |
| 30 mM | 0.1194 mL | 0.5970 mL | 1.1941 mL | 2.9851 mL | |
| 40 mM | 0.0896 mL | 0.4478 mL | 0.8955 mL | 2.2389 mL | |
| 50 mM | 0.0716 mL | 0.3582 mL | 0.7164 mL | 1.7911 mL | |
| 60 mM | 0.0597 mL | 0.2985 mL | 0.5970 mL | 1.4926 mL | |
| 80 mM | 0.0448 mL | 0.2239 mL | 0.4478 mL | 1.1194 mL | |
| 100 mM | 0.0358 mL | 0.1791 mL | 0.3582 mL | 0.8955 mL |
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