1. Immunology/Inflammation
    Protein Tyrosine Kinase/RTK
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  2. Aryl Hydrocarbon Receptor
    VEGFR
    Estrogen Receptor/ERR
  3. AhR modulator-1

AhR modulator-1 

Cat. No.: HY-135671
Handling Instructions

AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus.

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AhR modulator-1 Chemical Structure

AhR modulator-1 Chemical Structure

CAS No. : 115039-00-4

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Description

AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus[1].

IC50 & Target

Aryl hydrocarbon receptor (AhR) [1][2]
Prostatic VEGF[1]
Estrogenic[1]

In Vitro

AhR modulator-1 (6-MCDF; 0.1-10 μM; 48-96 hours; ASPC-1 cells) treatment exhibits dose-dependent growth inhibitory effects with growth inhibitory effects of 26, 43 and 99% at concentrations of 0.1, 1 and 10 μM, respectively[2].

Cell Proliferation Assay[2]

Cell Line: ASPC-1 cells
Concentration: 0.1 μM, 1 μM and 10 μM
Incubation Time: 48 hours, 72 hours, 96 hours
Result: Exhibited dose-dependent growth inhibitory effects.
In Vivo

AhR modulator-1 (6-MCDF; 0-40 mg/kg; oral administration; daily; for 12 weeks; C57BL/6-Tg(TRAMP)8247Ng/J mice) treatment reduces the frequency of pelvic lymph node metastasis in mice fed the 40 mg/kg diet. And serum VEGF concentrations are also reduced. Prostate tumor incidence and size are not significantly reduced[1].

Animal Model: C57BL/6-Tg(TRAMP)8247Ng/J (TRAMP) mice (8-week-old)[1]
Dosage: 0 mg/kg, 10 mg/kg, 40 mg/kg
Administration: Oral administration; daily; for 12 weeks
Result: The frequency of pelvic lymph node metastasis was reduced 5-fold in mice fed the 40 mg /kg diet.S erum VEGF concentrations were also reduced.
Molecular Weight

285.55

Formula

C₁₃H₇Cl₃O

CAS No.

115039-00-4

SMILES

CC1=C(OC2=CC(Cl)=CC(Cl)=C23)C3=CC(Cl)=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

AhR modulator-1AhR modulator1AhR modulator 1Aryl Hydrocarbon ReceptorVEGFREstrogen Receptor/ERRAhRVascular endothelial growth factor receptorant-proliferationanti-cancerVEGFmetastasisprostaticanti-estrogenicInhibitorinhibitorinhibit

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AhR modulator-1
Cat. No.:
HY-135671
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