1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

AFP464 

Cat. No.: HY-16031
Handling Instructions

AFP464, is an active HIF-1α inhibitor with an IC50 of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.

For research use only. We do not sell to patients.

AFP464 Chemical Structure

AFP464 Chemical Structure

CAS No. : 468719-52-0

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AFP464, is an active HIF-1α inhibitor with an IC50 of 0.25 μM, also is a potent aryl hydrocarbon receptor (AhR) activator.

IC50 & Target

IC50:0.25 μM (HIF-1α)[1]

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2300 mL 11.1498 mL 22.2995 mL
5 mM 0.4460 mL 2.2300 mL 4.4599 mL
10 mM 0.2230 mL 1.1150 mL 2.2300 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

448.44

Formula

C₂₂H₂₃F₃N₄O₃

CAS No.

468719-52-0

SMILES

O=C(NC1=CC=C(C2=CC(C3=C(N)C(F)=C(C)C(F)=C3O2)=O)C=C1F)[[email protected]@H](N)CCCCN

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
AFP464
Cat. No.:
HY-16031
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AFP464

Cat. No.: HY-16031