Aminoflavone
Aminoflavone is an anti-tumor agent. Aminoflavone inhibits the expression of ITGA6/SOX2 by activating the AhR-miR-125b-2-3p axis, thereby targeting breast cancer stem cells. Aminoflavone induces an increase in intracellular ROS, increases the level of oxidative DNA damage marker 8-oxodG and DNA-protein cross-links. Aminoflavone causes S-phase arrest, activates caspase-3/8/9 and induces apoptosis (apoptosis). Aminoflavone inhibits HIF-1α expression in a manner independent of AhR. Aminoflavone can be used for the study of breast cancer.
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- No. CAS: 165179-35-1
- Fòrmula: C16H11F3N2O2
- Peso molecular:320.27
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
35 nM
Compound: 5-AF
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Anticancer activity against human MCF7 cells assessed as inhibition of cell growth
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth
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[PMID: 26994845] |
| MCF7 | IC50 |
0.013 μM
Compound: 7a
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In vitro cytotoxicity against MCF-7 cell lines, treated for 3 days then uptake of neutral red dye was measured
In vitro cytotoxicity against MCF-7 cell lines, treated for 3 days then uptake of neutral red dye was measured
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[PMID: 9622547] |
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 165179-35-1
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Peso molecular 320.27
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Fòrmula C16H11F3N2O2
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SMILES
O=C1C=C(C2=CC=C(N)C(F)=C2)OC3=C(F)C(C)=C(F)C(N)=C13
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Synonyms
NSC-686288
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Aminoflavone Related Classifications
HY-132974 Related Classifications
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Keywords
- Aminoflavone
- 165179-35-1
- NSC-686288
- NSC686288
- NSC 686288
- Aryl Hydrocarbon Receptor
- Reactive Oxygen Species (ROS)
- DNA Alkylator/Crosslinker
- DNA/RNA Synthesis
- Caspase
- Apoptosis
- HIF/HIF Prolyl-Hydroxylase
- miR-125b-2-3p
- breast cancer stem cells
- oxidative DNA damage
- reactive oxygen species
- HIF-1α inhibition
- AhR-independent pathway
- Inhibitor
- inhibitor
- inhibit