1. GPCR/G Protein
  2. Adenosine Receptor
  3. Norisoboldine hydrochloride

Norisoboldine hydrochloride (Synonyms: (+)-Laurelliptine hydrochloride)

Cat. No.: HY-N0586A
Handling Instructions

Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis.

For research use only. We do not sell to patients.

Norisoboldine hydrochloride Chemical Structure

Norisoboldine hydrochloride Chemical Structure

CAS No. : 5083-84-1

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of Norisoboldine hydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis[1][2].

IC50 & Target

AhR[2]

In Vitro

Norisoboldine hydrochloride (1~30 μM; 0~24 hours; CD4+T cells) activates AhR under hypoxic microenvironment and significantly downregulates mRNA expression of miR-31[2].
Norisoboldine hydrochloride (30 μM; 0~24 hours; CD4+T cells) inhibits glycolysis in hypoxia[2].
Norisoboldine hydrochloride (1~30 μM; 0~72 hours; Treg cells) promotes Treg differentiation in hypoxia[2].
Norisoboldine hydrochloride (10, 30 μM) facilitates the disassociation of HSP90/AhR complexes, the nuclear translocation of AhR, and the formation of AhR/ARNT complexes. Norisoboldine hydrochloride induces generation of Treg cells in hypoxia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: CD4+T cells
Concentration: 1~30 μM
Incubation Time: 24 hours
Result: Activated AhR in cells under hypoxic microenvironment.

RT-PCR[2]

Cell Line: CD4+T cells
Concentration: 1~30 μM
Incubation Time: 24 hours
Result: Significantly downregulated mRNA expression of miR-31.

Immunofluorescence[2]

Cell Line: CD4+T cells
Concentration: 30 μM
Incubation Time: 24 hours
Result: Inhibited glycolysis in hypoxia.

Immunofluorescence[2]

Cell Line: Treg cells
Concentration: 1~30 μM
Incubation Time: 72 hours
Result: Promoted Treg differentiation in hypoxia.
In Vivo

Norisoboldine hydrochloride (10~40 mg/kg; p.o.; 20 days) significantly reduces the severity of joint swelling and erythema during the course of the experiment[1].
Norisoboldine hydrochloride (40 mg/kg; i.g.; 10 days) induces enhancement of CYP1A1 expression and suppresses expressions of Glut1 and HK2 in colons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (18–22 g)
Dosage: 10~40 mg/kg
Administration: P.o.
Result: Significantly reduced the severity of joint swelling and erythema during the course of the experiment.
Animal Model: Female C57BL/6 mice (18–22 g)
Dosage: 40 mg/kg
Administration: I.g.
Result: Induced enhancement of CYP1A1 expression and suppressed expressions of Glut1 and HK2 in colons.
Molecular Weight

349.81

Formula

C₁₈H₂₀ClNO₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Norisoboldine hydrochloride
Cat. No.:
HY-N0586A
Quantity:
MCE Japan Authorized Agent: