5083-84-1
Chemical Structure
Norisoboldine hydrochloride
Synonym(s): (+)-Laurelliptine hydrochloride
- CAS No.: 5083-84-1
- Formula:C18H20ClNO4
- Molecular Weight:349.81
IUPAC Name: (S)-2,10-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-1,9-diol hydrochloride
InChIKey: POXNVTUOIYRUGG-YDALLXLXSA-N
SMILES: [H]Cl.OC1=C(OC)C=C2CCN[C@@]3([H])CC4=CC(O)=C(OC)C=C4C1=C23
Biological Activity: Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis[1][2].
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Norisoboldine hydrochloride | 99.87% | Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis. | ||||||||||||||||||||
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Similarity Score 0.98
HY-N0586Norisoboldine -
Similarity Score 0.86
HY-N2352BLaurolitsine hydriodide -
Similarity Score 0.85
HY-N2352Laurolitsine -
Similarity Score 0.85
HY-117616Laurotetanine -
Similarity Score 0.84
HY-N4307Laetanine -
Similarity Score 0.82
HY-N9394(+)-Norlirioferine -
Similarity Score 0.81
HY-N9794Isoboldine -
Similarity Score 0.77
HY-N3177Norglaucine hydrochloride -
Similarity Score 0.76
HY-N9339Norglaucine -
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References
- [1]. Luo Y, et al. Therapeutic effect of norisoboldine, an alkaloid isolated from Radix Linderae, on collagen-induced arthritis in mice. Phytomedicine. 2010;17(10):726-731. [Content Brief]
- [2]. Lv Q, et al. Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD+/SIRT1/SUV39H1/H3K9me3 signaling pathway. Cell Death Dis. 2018;9(3):258. Published 2018 Feb 15. [Content Brief]
