1. PROTAC
    Epigenetics
  2. PROTAC
    Epigenetic Reader Domain
  3. β-NF-JQ1

β-NF-JQ1 

Cat. No.: HY-130256
Handling Instructions

β-NF-JQ1 is a PROTAC that recruits AhR E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity.

For research use only. We do not sell to patients.

β-NF-JQ1 Chemical Structure

β-NF-JQ1 Chemical Structure

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Description

β-NF-JQ1 is a PROTAC that recruits AhR E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity[1].

Molecular Weight

816.36

Formula

C₄₅H₄₂ClN₅O₆S

SMILES

O=C(NCCOCCOCCOCC1=CC=C(C2=CC(C3=C(O2)C=CC4=CC=CC=C34)=O)C=C1)C[[email protected]]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

β-NF-JQ1PROTACEpigenetic Reader DomainProteolysis-targeting chimeraInhibitorinhibitorinhibit

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β-NF-JQ1
Cat. No.:
HY-130256
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