CYP1A1 inhibitor 8a

Cat. No.: HY-120377 Purity: 98.00%: Data Sheet
COA

SDS
Handling Instructions
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CYP1A1 inhibitor 8a is a compound that potently and selectively inhibits the CYP1A1 enzyme and has the potential to prevent cancer. CYP1A1 inhibitor 8a exhibits more than 10-fold selectivity for CYP1A1 and more than 100-fold selectivity over other enzymes in the CYP1 subfamily. CYP1A1 inhibitor 8a can effectively antagonize B[a]P-mediated activation of the aryl hydrocarbon receptor (AhR) in yeast cells and protect human cells from CYP1A1-mediated B[a]P toxicity. CYP1A1 inhibitor 8a has the potential to be developed as a cancer chemopreventive agent.

For research use only. We do not sell to patients.

CYP1A1 inhibitor 8a Chemical Structure

CAS No. : 1821136-07-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

Molecular Weight

299.32

Formula

C₁₇H₁₇NO₄

CAS No.

1821136-07-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=NC=C1)/C=C/C2=CC(OC)=C(OC)C(OC)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (668.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3409 mL	16.7045 mL	33.4091 mL
5 mM	0.6682 mL	3.3409 mL	6.6818 mL
10 mM	0.3341 mL	1.6705 mL	3.3409 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.00%

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Data Sheet (270 KB) SDS (251 KB)

COA (247 KB) HNMR (167 KB) RP-HPLC (261 KB) MS (230 KB)

Handling Instructions (2659 KB)

References

[1]. (E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3409 mL	16.7045 mL	33.4091 mL	83.5226 mL
	5 mM	0.6682 mL	3.3409 mL	6.6818 mL	16.7045 mL
	10 mM	0.3341 mL	1.6705 mL	3.3409 mL	8.3523 mL
	15 mM	0.2227 mL	1.1136 mL	2.2273 mL	5.5682 mL
	20 mM	0.1670 mL	0.8352 mL	1.6705 mL	4.1761 mL
	25 mM	0.1336 mL	0.6682 mL	1.3364 mL	3.3409 mL
	30 mM	0.1114 mL	0.5568 mL	1.1136 mL	2.7841 mL
	40 mM	0.0835 mL	0.4176 mL	0.8352 mL	2.0881 mL
	50 mM	0.0668 mL	0.3341 mL	0.6682 mL	1.6705 mL
	60 mM	0.0557 mL	0.2784 mL	0.5568 mL	1.3920 mL
	80 mM	0.0418 mL	0.2088 mL	0.4176 mL	1.0440 mL
	100 mM	0.0334 mL	0.1670 mL	0.3341 mL	0.8352 mL