Carbidopa hydrochloride
Based on 2 publication(s) in Google Scholar
Carbidopa hydrochloride ((S)-(-)-Carbidopa hydrochloride) is a drug used to inhibit Parkinson's disease, which has the activity of inhibiting the peripheral metabolism of levodopa. Carbidopa hydrochloride can increase the proportion of peripheral levodopa penetrating the blood-brain barrier, thereby enhancing its effect on the central nervous system. Carbidopa hydrochloride has also been found to be an aryl hydrocarbon receptor (AhR) ligand with anticancer activity, which can inhibit the growth of pancreatic cancer cells and tumors. The selective AhR regulation properties of carbidopa hydrochloride provide potential prospects for its clinical application.
For research use only. We do not sell to patients.
- CAS No.: 65132-60-7
- Formula: C10H15ClN2O4
- Molecular Weight:262.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Carbidopa hydrochloride
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
Biological Activity
Chemical Information
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CAS No. 65132-60-7
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Molecular Weight 262.69
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Formula C10H15ClN2O4
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SMILES
OC(C=C1C[C@@](NN)(C)C(O)=O)=C(C=C1)O.Cl
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Synonyms
(S)-(-)-Carbidopa hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Sci Data
High-throughput drug screening identifies novel therapeutics for Low Grade Serous Ovarian Carcinoma. [Abstract]2024 Sep 19;11(1):1024. PMID: 39300112 -
Carbidopa hydrochloride purchased from MedChemExpress. Usage Cited in: SSRN. 2026 Mar 6.
Carbidopa treatment 455 significantly attenuated the growth-promoting effects of aspartame-treated A. muciniphila supernatants 456 on MC38 cells
Carbidopa hydrochloride purchased from MedChemExpress. Usage Cited in: SSRN. 2026 Mar 6.
Carbidopa effectively blocked the proliferative effects of 457 exogenous 5-HTP treatment.
Purity & Documentation
References
[1]. Carbidopa: a selective Ah receptor modulator (SAhRM) [Content Brief]
[2]. Safe S. Carbidopa: a selective Ah receptor modulator (SAhRM). Biochem J. 2017;474(22):3763-3765. Published 2017 Nov 6. [Content Brief]
[3]. Fermaglich J. Treatment of Parkinson's disease with carbidopa, a peripheral decarboxylase inhibitor, and levodopa. Med Ann Dist Columbia. 1974;43(12):587-591. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)