2. Apoptosis Immunology/Inflammation
  3. Pyroptosis
  4. PenCB

PenCB (PCB 118) could induces pyroptosis by priming and activating NFκB-dependent NLRP3 inflammasome. PCB 118 induces oxidative stress and pyroptosis are dependent on Aryl hydrocarbon receptor (AhR) activation and subsequent cytochrome P450 1A1 upregulation.

For research use only. We do not sell to patients.

PenCB Chemical Structure

PenCB Chemical Structure

CAS No. : 31508-00-6

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PenCB Related Antibodies

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Description

PenCB (PCB 118) could induces pyroptosis by priming and activating NFκB-dependent NLRP3 inflammasome. PCB 118 induces oxidative stress and pyroptosis are dependent on Aryl hydrocarbon receptor (AhR) activation and subsequent cytochrome P450 1A1 upregulation[1].

In Vitro

PCB 118 exposure-induces oxidative stress leads to NLRP3 inflammasome-dependent pyroptosis in endothelial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PenCB Related Antibodies
Molecular Weight

326.43

Formula

C12H5Cl5
CAS No.
SMILES

ClC1=C(C=C(C(C2=CC=C(C(Cl)=C2)Cl)=C1)Cl)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PenCB Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PenCB31508-00-6PCB 118PCB118PCB-118Pyroptosisoxidative stressAhRcytochrome P450inflammasomeInhibitorinhibitorinhibit

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HY-117532
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