AhR agonist 2
Based on 1 publication(s) in Google Scholar
AhR agonist 2 (Compound 12a) is a potent agonist of aryl hydrocarbon receptor (AhR) with an EC50 of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers the transcription of downstream genes and promote skin barrier repair. AhR agonist 2 has the potential for the research of psoriasis.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 2975270-19-8
- Formula: C12H7Br2N3
- Molecular Weight:353.01
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AhR agonist 2
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BEAS-2B | IC50 |
>300 μM
Compound: 12a
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Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 35123295] |
| HEK-293T | IC50 |
>300 μM
Compound: 12a
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Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 35123295] |
| HUVEC | IC50 |
>300 μM
Compound: 12a
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Cytotoxicity against human HUVEC cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 35123295] |
| LX-2 | IC50 |
>300 μM
Compound: 12a
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Cytotoxicity against human LX2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human LX2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
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[PMID: 35123295] |
Chemical Information
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CAS No. 2975270-19-8
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Appearance Solid
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Molecular Weight 353.01
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Formula C12H7Br2N3
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Color Off-white to light yellow
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SMILES
BrC1=CC=C(C=C1)C2=NN3C=C(C=CC3=N2)Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochim Biophys Acta Mol Basis Dis
Hypoxia-driven heterogeneous expression of α5 integrin in glioblastoma stem cells is linked to HIF-2α. [Abstract]2024 Aug 16:167471. PMID: 39154793
Solvent & Solubility
DMSO : 20.83 mg/mL (59.01 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8328 mL | 14.1639 mL | 28.3278 mL | 70.8195 mL |
| 5 mM | 0.5666 mL | 2.8328 mL | 5.6656 mL | 14.1639 mL | |
| 10 mM | 0.2833 mL | 1.4164 mL | 2.8328 mL | 7.0820 mL | |
| 15 mM | 0.1889 mL | 0.9443 mL | 1.8885 mL | 4.7213 mL | |
| 20 mM | 0.1416 mL | 0.7082 mL | 1.4164 mL | 3.5410 mL | |
| 25 mM | 0.1133 mL | 0.5666 mL | 1.1331 mL | 2.8328 mL | |
| 30 mM | 0.0944 mL | 0.4721 mL | 0.9443 mL | 2.3607 mL | |
| 40 mM | 0.0708 mL | 0.3541 mL | 0.7082 mL | 1.7705 mL | |
| 50 mM | 0.0567 mL | 0.2833 mL | 0.5666 mL | 1.4164 mL |
AhR agonist 2 Related Classifications
HY-144339 Related Classifications
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