AHRR Antibody (YA9367)
(Synonyms: BHLHE77, KIAA1234, AHRR, Aryl hydrocarbon receptor repressor, AhR repressor, AhRR, Class E basic helix-loop-helix protein 77, bHLHe77)
Based on 1 Customer Validation
AHRR Antibody (YA9367) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AHRR.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IP, ELISA
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Reactivity :
human
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1-2μg per 100-500μg Total protein | 1:50-3000 |
Product Details
AHRR Antibody (YA9367) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AHRR.
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Host Mouse
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Species Reactivityhuman
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Calculated Molecular Weight Predicted band size: 80 kDa
OMIM: 606517
A synthesized peptide derived from human AHRR.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
AHRR mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with AHR for heterodimer formation with ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of a variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Tissue_Specificity: Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Down-regulated in malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary.
Induction: By 3-methylcholanthrene (3-MC) in MNCs from adults. By the heterodimer AHR/ARNT. -
Isoforms & Post-Translational Modification
AHRR has 2 isoforms, A9YTQ3-1: amino acid length is 697, molecular weight is 75780 Da (predicted); A9YTQ3-3: amino acid length is 715, molecular weight is 77821 Da (predicted).
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Subunit
Heterodimer with ARNT; formation of the heterodimer results in repression of the transcription activity of AHR.
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SwissProt ID
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Synonyms
BHLHE77, KIAA1234, AHRR, Aryl hydrocarbon receptor repressor, AhR repressor, AhRR, Class E basic helix-loop-helix protein 77, bHLHe77
Documentation
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