AHRR - aryl hydrocarbon receptor repressor Gene

Also Known as AHH; AHHR; bHLHe77

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57491

About AHRR

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:321,714-438,285 (from NCBI)

This gene has 11 transcripts (splice variants), 227 orthologues and 1 paralogue. Broad expression in testis (RPKM 4.1), spleen (RPKM 2.9) and 21 other tissues.

Summary

The protein encoded by this gene participates in the Aryl Hydrocarbon Receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

AHRR Products (2)

mRNA Protein Name
NM_001377236.1 NP_001364165.1 aryl hydrocarbon receptor repressor
NM_001377239.1 NP_001364168.1 aryl hydrocarbon receptor repressor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28904176 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AHRR Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (38 - 79)

PAS

PAS: PAS fold (116 - 179)

  • 0
  • 200
  • 400
  • 600
  • 701 a.a.
Protein Preferred Names Protein Names

aryl hydrocarbon receptor repressor

  • ahR repressor

AHRR Antibodies

Cat. No. Product Name Application Reactivity
HY-P810023 AHRR Antibody (YA9367) WB, IP, ELISA human

Related Diseases

Diseases Alias
Aryl Hydrocarbon Hydroxylase Inducibility

  • Ahh Inducibility

  • Ahhi
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00484 AHRR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03441 CYP1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16737 Cyp1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19573 Ahrr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23174 Cyp1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26070 Ahrr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W517092 1,2,3,4,7,8,9-Heptachlorodibenzofuran / Unkown
HY-W775354 1,2,3,4,7,8-Hexachlorodibenzofuran / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus AHRR MGD MGI:1333776
Macaca mulatta AHRR VGNC VGNC:108143
Felis catus AHRR VGNC VGNC:101455
Canis familiaris AHRR VGNC VGNC:37729
Rattus norvegicus AHRR RGD RGD:1559857
Others AHRR NCBI