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Results for "

mGlu

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (8) Cytochrome P450 (1) EGFR (3) Endogenous Metabolite (3) ERK (1) mGluR (167) p38 MAPK (3) PERK (1) Reference Standards (19)
By Research Areas:	Cancer (11) Infection (2) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (155)

168

Inhibitors & Agonists

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100407

JNJ16259685 3 Publications Verification	mGluR	Neurological Disease
JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC₅₀ of 19 nM.

HY-70059

LY341495 Maximum Cited Publications 14 Publications Verification	mGluR	Neurological Disease
LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC₅₀s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors, respectively .

HY-103558

LY379268 1 Publications Verification	mGluR	Neurological Disease
LY379268 is a potent, selective and brain-penetrant *mGlu2/3R* agonist with EC₅₀ values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects .

HY-100781A

L-AP4 1 Publications Verification L-APB	mGluR	Neurological Disease
L-AP4 (L-APB) is a potent and specific agonist for the group III mGluRs, with EC₅₀s of 0.13, 0.29, 1.0, 249 μM for mGlu₄, mGlu₈, mGlu₆ and mGlu₇ receptors, respectively .

HY-W011417

Cinnabarinic acid 1 Publications Verification	Endogenous Metabolite mGluR Apoptosis	Others
Cinnabarinic acid is a specific orthosteric agonist of *mGlu₄* by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of tryptophan. Cinnabarinic acid induces cell apoptosis .

HY-15445

CTEP 2 Publications Verification RO 4956371; mGluR5 inhibitor	mGluR	Neurological Disease
CTEP (RO 4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC₅₀ of 2.2 nM, and shows > 1000-fold selectivity over other mGlu receptors. CTEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101335

DCG-IV	mGluR	Neurological Disease
DCG-IV is a potent agonist of group II mGluRs with EC₅₀s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC₅₀: mGlu1R/5R=389/630 μM) and III receptors (IC₅₀: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects .

HY-18941

Eglumegad 4 Publications Verification LY354740; Eglumetad	mGluR	Neurological Disease
Eglumegad (LY354740) is a highly potent and selective *group II (mGlu2/3) receptor* agonist with IC₅₀s of 5 nM and 24 nM on transfected human *mGlu2* and *mGlu3* receptors, respectively.

HY-19559

JNJ-46778212 VU 0409551	mGluR	Neurological Disease
JNJ-46778212 (VU 0409551) is an *mGlu5* positive allosteric modulator with an EC₅₀ of 260 nM.

HY-124419

RO0711401 2 Publications Verification	mGluR	Neurological Disease
RO0711401 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC₅₀ of 56 nM .

HY-107982

VU6005649	mGluR	Neurological Disease
VU6005649 is a blood-brain-barrier penetrant mGlu_7/8 receptor agonist with EC₅₀s of 0.65 μM and 2.6 μM for mGlu₇ receptor and mGlu₈ receptor, respectively.

HY-100366

Lu AF21934	mGluR	Neurological Disease
Lu AF21934 is a selective and brain-penetrant *mGlu4* receptor positive allosteric modulator with an EC₅₀ of 500 nM for mGlu4 receptor .

HY-W011417R

Cinnabarinic acid (Standard)	Endogenous Metabolite Reference Standards mGluR Apoptosis	Others
Cinnabarinic acid (Standard) is the analytical standard of Cinnabarinic acid. This product is intended for research and analytical applications. Cinnabarinic acid is a specific orthosteric agonist of *mGlu₄* by interacting with residues of the glutamate binding pocket of mGlu4, has no activity at other mGlu receptors. Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway of tryptophan. Cinnabarinic acid induces cell apoptosis .

HY-101333

CPPG (RS)-CPPG	mGluR	Neurological Disease
CPPG ((RS)-CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC₅₀=2.2 nM) over group II (IC₅₀=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors .

HY-101845

FITM 1 Publications Verification	mGluR	Cancer
FITM is a negative allosteric modulator of *mGlu1* receptor with a K_i of 2.5 nM.

HY-102095

SIB-1757	mGluR	Neurological Disease
SIB-1757 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC₅₀ of 0.4 μM .

HY-100588

VU0364770	mGluR	Neurological Disease
VU0364770 is a selective and potent positive allosteric modulator (PAM) of *mGlu4. VU0346770 exhibits EC₅₀s of 290 nM and 1.1 μM at rat mGlu4* and *human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu*6 with a potency of 6.8 μM. VU0364770 also possesses activity at MAO with K_i values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively .

HY-117764

LSP4-2022	mGluR	Neurological Disease
LSP4-2022 is a potent and brain-penetrant *mGlu4*-selective orthosteric agonist, with an EC₅₀ of 0.11 μM. LSP4-2022 inhibits neurotransmission in cerebellar slices from wild-type but not *mGlu4* receptor-knockout mice. LSP4-2022 shows pro-depressant activity .

HY-19630

ML289 VU0463597	mGluR	Neurological Disease
ML289 (VU0463597) is a potent, selective, and CNS-penetrant *mGlu3* (IC₅₀=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5 . ML289 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-123820

LY3020371 hydrochloride 1 Publications Verification	mGluR	Neurological Disease
LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with K_i of 5.3 and 2.5 nM, potently blocks cAMP formation with IC₅₀ of 16.2 nM . LY3020371 hydrochloride exerts an antidepressant-like signature in vivo .

HY-120589

VU0360172	mGluR	Neurological Disease
VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC₅₀ value of 16 nM and a K_i of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice . VU0360172 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-122255

LY487379	mGluR	Neurological Disease
LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [ ³⁵S]GTPγS binding with EC₅₀ values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research .

HY-18941C

Eglumegad hydrochloride 4 Publications Verification LY354740 hydrochloride; Eglumetad hydrochloride	mGluR	Neurological Disease
Eglumegad (LY354740) hydrochloride is a highly potent and selective *group II (mGlu2/3) receptor* agonist with IC₅₀s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. Eglumegad hydrochloride protects neurons from NMDA toxicity. Eglumegad hydrochloride has anxiolytic- and antipsychotic-like effects .

HY-156331

VU6004909	mGluR	Neurological Disease
VU6004909 is a blood-brain barrier penetrated mGlu1* positive* allosteric modulator (PAM), with the EC₅₀s of 25.7 nM and 31 nM for human mGlu1 and rat mGlu1, respectively. VU6004909 reduces dorsolateral striatal dopamine (DA) release in vivo and displays antipsychotic efficacy .

HY-110146

XAP044	mGluR	Neurological Disease
XAP044 is a potent and selective antagonist of *mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu*7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms .

HY-131286A

Talaglumetad hydrochloride LY-544344 hydrochloride	mGluR	Neurological Disease
Talaglumetad (LY-544344) hydrochloride is a prodrug of *mGlu2/3* receptor agonist Eglumetad (HY-18941). Talaglumetad hydrochloride exhibits anxiolytic activity and reverses fear-induced suppression of operant responding. Talaglumetad hydrochloride shows anxiolytic effects in CCK-4-induced panic and anxiety studies. Talaglumetad hydrochloride can be used in studies on the mechanisms associated with generalized anxiety disorder .

HY-18760

LY2812223	mGluR	Neurological Disease
LY2812223 is a highly potent, functionally selective mGlu₂ receptor agonist with mGlu₂ binding affinity for mGlu₂ and mGlu₃ (K_i=144 nM and 156 nM, respectively) .

HY-70059A

(Rac)-LY341495	mGluR	Neurological Disease
(Rac)-LY341495 is the isomers of LY341495 (HY-70059) can be used as control compounds in experiments. LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC₅₀s of 21 nM, 14 nM, 7.8 μM, 8.2 μM, 170 nM, 990 nM, 22 μM for mGlu2, mGlu3, mGlu1a, mGlu5a, mGlu8, mGlu7, and mGlu4 receptors, respectively .

HY-15393

VU 0357121	mGluR	Neurological Disease
VU 0357121 is a positive and highly selective *mGlu5R* allosteric modulator (PAM) with an EC₅₀ of 33 nM. VU 0357121 is inactive or very weakly antagonizing at other mGlu receptor subtypes .

HY-105040C

Pomaglumetad methionil hydrochloride LY2140023 hydrochloride	mGluR	Neurological Disease
Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research .

HY-101311

UPF-523 AIDA	mGluR	Inflammation/Immunology Cancer
UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors *(mGlu1a)* with an IC₅₀ of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis .

HY-103550

A-841720	mGluR	Neurological Disease
A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC₅₀ of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC₅₀ of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research .

HY-100605

VU0483605	mGluR	Others
VU0483605 is a potent and brain-penetrated *mGlu₁* receptor positive allosteric modulator (PAM). VU0483605 shows excellent *mGlu₁* PAM activity at both human and rat, with EC₅₀ values of 390 and 356 nM, respectively .

HY-13239

LY2979165	mGluR	Neurological Disease
LY2979165 is the alanine proagent of 2812223, a selective and potent orthosteric *mGlu2* receptor agonist .

HY-18162

JNJ-42153605	mGluR	Neurological Disease
JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC₅₀ of 17 nM.

HY-118179

VU0486321	mGluR	Neurological Disease
VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity.

HY-103549

Z-Cyclopentyl-AP4	mGluR	Neurological Disease
Z-Cyclopentyl-AP4 is a kainate-type glutamate receptor agonist (orthosteric agonist). Z-Cyclopentyl-AP4 is more selective for *mGlu4* than mGlu8 .

HY-15476

VU 0364439	mGluR	Neurological Disease
VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM.

HY-14419

TCN238	mGluR	Neurological Disease
TCN238 is an orally bioavailable *mGlu4* receptor positive allosteric modulator (PAM) with an EC₅₀ of 1 μM .

HY-19623

VU0092273	mGluR	Neurological Disease
VU0092273 is a potent *mGlu5* positive allosteric modulator (PAM) that also binds to the MPEP site, with an EC₅₀ of 0.27 μM .

HY-103559

HexylHIBO	mGluR	Neurological Disease
HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 μM and 110 μM at mGlu_1a and mGlu_5a receptors, respectively. HexylHIBO does not inhibits mGlu2 and mGlu4a. HexylHIBO decreased spontaneous excitatory postsynaptic currents (sEPSCs) in rat .

HY-100781B

L-AP4 monohydrate L-APB monohydrate	mGluR	Neurological Disease
L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC₅₀s of 0.13, 0.29, 1.0, 249 μM for mGlu₄, mGlu₈, mGlu₆ and mGlu₇ receptors, respectively .

HY-100841A

(S)-3-Hydroxyphenylglycine (S)-3HPG	mGluR	Neurological Disease
(S)-3-Hydroxyphenylglycine ((S)-3HPG) is a potent mGluR₁ agonist without effect at mGlu₂ or mGlu₄ .

HY-14554

Pomaglumetad methionil anhydrous LY2140023	mGluR	Neurological Disease
Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research .

HY-116855

TASP0433864	mGluR	Neurological Disease
TASP0433864 is a selective positive allosteric modulator (PAM) of *metabotropic glutamate 2 (mGlu2) receptor* with EC₅₀ values of 199 nM and 206 nM against human and rat mGlu2 receptors, respectively. TASP0433864 has antipsychotic activity .

HY-105040

Pomaglumetad methionil LY2140023 hydrate	mGluR	Neurological Disease
Pomaglumetad methionil (LY2140023 hydrate) is an oral methionine prodrug of the potent specific mGlu2/3 receptor agonist LY404039 (HY-50906). Pomaglumetad methionil is well-tolerated and has a distinct safety profile, and can be used for schizophrenia .

HY-W565924

STX107	mGluR ERK	Neurological Disease
STX107 is a *metabotropic glutamate 5 (mGlu5) receptor* negative allosteric modulator (NAM) with a pK_i of 8.32. STX107 inhibits glutamate-induced Ca ²⁺ mobilization, IP1 accumulation, and ERK1/2 phosphorylation. STX107 also inhibits glutamate-induced mGlu5 internalization .

HY-110191

VU0469650	mGluR	Neurological Disease Cancer
VU0469650 is a potent, selective and brain-penetrant negative allosteric modulator of *mGlu₁* receptor, with an IC₅₀ of 99 nM .

HY-103551

(±)-LY395756	mGluR	Neurological Disease
(±)-LY395756 is an agonist of mGlu2 receptor and an antagonist of mGlu3 receptor. (±)-LY395756 can distinguish the native mGlu2 and mGlu3 receptors .

HY-144698

mGlu4 receptor agonist 1	mGluR	Neurological Disease
mGlu4 receptor agonist 1 (compound 62) is a potent *mGlu4* receptor positive allosteric modulator, with an EC₅₀ of 308 nM. mGlu4 receptor agonist 1 shows significant anxiolytic- and antipsychotic-like effect .

Host:	Mouse (12) Rabbit (1)
Reactivity:	Human (13) Rat (3) Mouse (3)
Application:	IHC-P (6) ICC/IF (6) WB (5) FC (8) ELISA (10)
Isotype:	IgG (1) IgG1 (8) IgG2a (4)
Conjugation:	Non-conjugated (13)
Clonality:	Monoclonal (5) Monoclonal Antibody (2) Recombinant (1)
Modification:	Unmodified (7)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88120

	GRM4 Antibody (YA7804) GPRC1D; mGlu4; mGluR4	IHC-P	Human, Mouse, Rat
	GRM4 Antibody (YA7804) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GRM4.

HY-P83787

	GRM8 Antibody (YA3484) GLUR8; mGlu8; GPRC1H; mGluR8	WB, FC, ELISA	Human
	GRM8 Antibody (YA3484) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM8.

HY-P88120A

	GRM4 Antibody (YA7804)(PBS only) GPRC1D; mGlu4; mGluR4	IHC-P	Human, Mouse, Rat
	GRM4 Antibody (YA7804) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to GRM4.

HY-P83787A

	GRM8 Antibody (YA3484)(PBS only) GLUR8; mGlu8; GPRC1H; mGluR8	WB, FC, ELISA	Human
	GRM8 Antibody (YA3484) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM8.

HY-P84578

	Metabotropic Glutamate Receptor 3 Antibody (YA4275) GLUR3; mGlu3; GPRC1C; mGluR3	IHC-P, ICC/IF, FC, ELISA	Human
	Metabotropic Glutamate Receptor 3 Antibody (YA4275) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Metabotropic Glutamate Receptor 3.

HY-P84569

	Metabotropic Glutamate Receptor 2 Antibody (YA4266) GLUR2; mGlu2; GPRC1B; mGluR2	WB, FC, ELISA	Human
	Metabotropic Glutamate Receptor 2 Antibody (YA4266) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.

HY-P84577

	GRM7 Antibody (YA4274) GLUR7; mGlu7; GPRC1G; mGluR7; PPP1R87	ICC/IF, FC, ELISA	Human
	GRM7 Antibody (YA4274) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM7.

HY-P83232

	Metabotropic Glutamate Receptor 3 Antibody (YA2977) GLUR3; GPRC1C; GRM3; mGlu3; mGluR3	WB	Human, Mouse, Rat
	Metabotropic Glutamate Receptor 3 Antibody (YA2977) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Metabotropic Glutamate Receptor 3.

HY-P84310

	Metabotropic glutamate receptor 5 Antibody (YA4007) mGlu5; GPRC1E; mGluR5; PPP1R86	IHC-P, ICC/IF, ELISA	Human
	Metabotropic glutamate receptor 5 Antibody (YA4007) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic glutamate receptor 5.

HY-P84569A

	Metabotropic Glutamate Receptor 2 Antibody (YA4266)(PBS only) GLUR2; mGlu2; GPRC1B; mGluR2	WB, FC, ELISA	Human
	Metabotropic Glutamate Receptor 2 Antibody (YA4266) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic Glutamate Receptor 2.

HY-P84577A

	GRM7 Antibody (YA4274)(PBS only) GLUR7; mGlu7; GPRC1G; mGluR7; PPP1R87	ICC/IF, FC, ELISA	Human
	GRM7 Antibody (YA4274) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRM7.

HY-P84578A

	Metabotropic Glutamate Receptor 3 Antibody (YA4275)(PBS only) GLUR3; mGlu3; GPRC1C; mGluR3	IHC-P, ICC/IF, FC, ELISA	Human
	Metabotropic Glutamate Receptor 3 Antibody (YA4275) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Metabotropic Glutamate Receptor 3.

HY-P84310A

	Metabotropic glutamate receptor 5 Antibody (YA4007)(PBS only) mGlu5; GPRC1E; mGluR5; PPP1R86	IHC-P, ICC/IF, ELISA	Human
	Metabotropic glutamate receptor 5 Antibody (YA4007) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Metabotropic glutamate receptor 5.

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