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Cat. No.: HY-100366R

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Lu AF21934 (Standard)

Lu AF21934 (Standard) is the analytical standard of Lu AF21934 (HY-100366). This product is intended for research and analytical applications. Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an EC50 of 500 nM for mGlu4 receptor.

For research use only. We do not sell to patients.

CAS No.: 1445605-23-1
Formula: C₁₄H₁₆Cl₂N₂O₂
Molecular Weight:315.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Lu AF21934 (Standard) Chemical Structure

CAS No.: 1445605-23-1

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Fluorescent Dye

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1445605-23-1
Molecular Weight 315.20
Formula C₁₄H₁₆Cl₂N₂O₂
SMILES

O=C([C@@H]1[C@H](C(N)=O)CCCC1)NC2=CC=C(Cl)C(Cl)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Anna Sławińska, et al. Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu? receptor. Neuropharmacology. 2013 Mar;66:225-35. [Content Brief]

[2]. Ossowska K, et al. Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats. Neuropharmacology. 2014 Aug;83:28-35. [Content Brief]

[3]. Anna Sławińska, et al. The antipsychotic-like effects of positive allosteric modulators of metabotropic glutamate mGlu4 receptors in rodents. Br J Pharmacol. 2013 Aug;169(8):1824-39. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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