1. GPCR/G Protein
  2. mGluR

PHCCC 

Cat. No.: HY-100409 Purity: 99.80%
Data Sheet SDS Handling Instructions

PHCCC is a Group I metabotropic glutamate receptor antagonist with EC 50 of 6 uM and a positive allosteric modulator of mGluR4. Also as a potent to antagonism for mGluR2 and mGluR8.

For research use only. We do not sell to patients.
PHCCC Chemical Structure

PHCCC Chemical Structure

CAS No. : 179068-02-1

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $66 In-stock
5 mg $60 In-stock
10 mg $100 In-stock
25 mg $220 In-stock
50 mg $380 In-stock
100 mg $660 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

PHCCC is a Group I metabotropic glutamate receptor antagonist with EC50 of 6 uM and a positive allosteric modulator of mGluR4. Also as a potent to antagonism for mGluR2 and mGluR8. target: a Group I metabotropic glutamate receptor antagonist EC 50: 6 uM In vitro: PHCCC potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro. In vivo: 1, PHCCC produced antiparkinsonian efficacy in the reserpinized rat model means a significant level of glutamate is available for the activation of the therapeutically relevant mGluR4. 2, The reference for animal administration is 10 mg/kg.(i.p) 3,PHCCC augmentes in vivo genetic and pharmacological models of absence seizures in rats.

References
Molecular Weight

294.3

Formula

C₁₇H₁₄N₂O₃

CAS No.

179068-02-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
PHCCC
Cat. No.:
HY-100409
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