1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. PHCCC

PHCCC 

Cat. No.: HY-100409 Purity: 99.96%
Handling Instructions

PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect.

For research use only. We do not sell to patients.

PHCCC Chemical Structure

PHCCC Chemical Structure

CAS No. : 179068-02-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 81 In-stock
Estimated Time of Arrival: December 31
2 mg USD 50 In-stock
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5 mg USD 70 In-stock
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10 mg USD 115 In-stock
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25 mg USD 250 In-stock
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50 mg USD 450 In-stock
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100 mg USD 780 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect[1][2].

IC50 & Target[1] [1]

Group I mGluR receptors

3 μM (IC50)

In Vitro

PHCCC potentiated the effect of L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) in inhibiting transmission at the striatopallidal synapse[2].

In Vivo

PHCCC (75 nmol/2.5 μl; intracerebroventricular) produces an antiparkinsonian effect in a dopamine depletion akinesia model[2].

Molecular Weight

294.30

Formula

C₁₇H₁₄N₂O₃

CAS No.

179068-02-1

SMILES

O=C(C12C(C2)/C(C3=CC=CC=C3O1)=N\O)NC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (42.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3979 mL 16.9895 mL 33.9789 mL
5 mM 0.6796 mL 3.3979 mL 6.7958 mL
10 mM 0.3398 mL 1.6989 mL 3.3979 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (4.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (4.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (4.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PHCCCmGluRMetabotropic glutamate receptorsneuronsneuroprotectiveParkinson'sdiseaseallostericInhibitorinhibitorinhibit

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PHCCC
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