179068-02-1
179068-02-1
Chemical Structure
PHCCC
- CAS No.: 179068-02-1
- Formula:C17H14N2O3
- Molecular Weight:294.31
IUPAC Name: (E)-7-(hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide
InChIKey: FPXPIEZPAXSELW-CYVLTUHYSA-N
SMILES: O=C(C12C(C2)/C(C3=CC=CC=C3O1)=N\O)NC4=CC=CC=C4
Biological Activity: PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect[1][2].
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PHCCC | 99.92% | PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect. | ||||||||||||||||||||
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PHCCC (Standard) | ≥98% | PHCCC (Standard) is the analytical standard of PHCCC (HY-100409). This product is intended for research and analytical applications. PHCCC is a Group I mGluR antagonist with an IC50 of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect. | ||||||||||||||||||||
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References
- [1]. Récasens M, et al. Metabotropic glutamate receptors as drug targets. Curr Drug Targets. 2007;8(5):651-681. [Content Brief]
- [2]. Marino MJ et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73. [Content Brief]
Keywords
