mGluR Antagonist

mGluR Antagonists (22):

Cat. No.	Product Name	Effect	Purity

HY-100371

(RS)-MCPG	Antagonist	99.05%
(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons.

HY-100406

(S)-MCPG	Antagonist	99.23%
(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.

HY-103566

LY456236	Antagonist	99.81%
LY456236 is a selective, non-competitive and orally active mGlu1 receptor antagonist that inhibits phosphoinositide hydrolysis with an IC₅₀ of 0.145 μM. LY456236 also inhibits EGFR with an IC₅₀ of 0.91 μM.

HY-100372

E4CPG	Antagonist	≥98.0%
E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation.

HY-102094

(E/Z)-SIB-1893	Antagonist	99.79%
(E/Z)-SIB-1893 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist.

HY-100409

PHCCC	Antagonist	99.96%
PHCCC is a Group I mGluR antagonist with an IC₅₀ of 3 μM. PHCCC is a selective positive modulator of mGlu4 receptor. Antiparkinsonian effect.

HY-155352

mGluR5 antagonist-1	Antagonist	98.80%
mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC₅₀ value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect.

HY-103567

Desmethyl-YM-298198 hydrochloride	Antagonist
Desmethyl-YM-298198 hydrochloride is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC₅₀: 16 nM). Desmethyl-YM-298198 hydrochloride has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice.

HY-103564

ACDPP	Antagonist
ACDPP is a specific mGluR5 antagonist. ACDPP partially bolcks the increase of fragile X mental retardation protein (FMRP) caused by DHPG (HY-12598A) (group I mGluR Agonist).

HY-103571

VU0285683	Antagonist
VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety.

HY-103570

MCPG sodium	Antagonist
MCPG is a carboxylic phenyl glycine. MCPG can block metabotropic glutamate receptor (mGluR)(HY-15129) and has antagonistic activity of mGluR subtype. MCPG can be used to study the induction and maintenance of long-term potentiation (LTP) .

HY-103557

Ro 64-5229	Antagonist
Ro 64-5229 is a selective, non-competitive mGlu2 antagonist. RO 64-5229 reduces the presynaptic inhibitory effect of Neuroligin 1.

HY-110146

XAP044	Antagonist
XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms.

HY-135464

(±)-LY367385	Antagonist	≥98.0%
(±)-LY367385 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC₅₀ of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a.

HY-101164

MAP4	Antagonist
MAP4 is a selective group III mGluR antagonist in some electrophysiological systems.

HY-130553

β-Spaglumic acid	Antagonist
β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (K_i=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies.

HY-103559

HexylHIBO	Antagonist
HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 and 110 μM at mGlu_1a and mGlu_5a receptors, respectively. HexylHIBO decreased sEPSC in rat.

HY-108546

L-AP3	Antagonist
L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibits D-phosphoserine and L-phosphoserine with IC₅₀s of 368 μM and 2087 μM, respectively.

HY-103551

(±)-LY395756	Antagonist
(±)-LY395756 is an agonist of mGlu2 receptor and an antagonist of mGlu3 receptor. (±)-LY395756 can distinguish the native mGlu2 and mGlu3 receptors.

HY-103232

IEM-1925 bromide	Antagonist
IEM-1925 bromide is an orally active glutamate receptor antagonist, increases the latent period and decreases the duration of status epilepticus in rats in a lithium-pilocarpine model of epilepsy.

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