VU0285683
Based on 1 Customer Validation
VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 327056-22-4
- Formula: C14H7FN4O
- Molecular Weight:266.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.025 μM
Compound: 7s
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Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellular Ca2+ level after 30 mins by FLIPR assay
Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellular Ca2+ level after 30 mins by FLIPR assay
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[PMID: 23046966] |
Chemical Information
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CAS No. 327056-22-4
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Appearance Solid
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Molecular Weight 266.23
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Formula C14H7FN4O
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Color White to off-white
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SMILES
N#CC1=CC(C2=NC(C3=NC=CC=C3)=NO2)=CC(F)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (187.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7562 mL | 18.7808 mL | 37.5615 mL | 93.9038 mL |
| 5 mM | 0.7512 mL | 3.7562 mL | 7.5123 mL | 18.7808 mL | |
| 10 mM | 0.3756 mL | 1.8781 mL | 3.7562 mL | 9.3904 mL | |
| 15 mM | 0.2504 mL | 1.2521 mL | 2.5041 mL | 6.2603 mL | |
| 20 mM | 0.1878 mL | 0.9390 mL | 1.8781 mL | 4.6952 mL | |
| 25 mM | 0.1502 mL | 0.7512 mL | 1.5025 mL | 3.7562 mL | |
| 30 mM | 0.1252 mL | 0.6260 mL | 1.2521 mL | 3.1301 mL | |
| 40 mM | 0.0939 mL | 0.4695 mL | 0.9390 mL | 2.3476 mL | |
| 50 mM | 0.0751 mL | 0.3756 mL | 0.7512 mL | 1.8781 mL | |
| 60 mM | 0.0626 mL | 0.3130 mL | 0.6260 mL | 1.5651 mL | |
| 80 mM | 0.0470 mL | 0.2348 mL | 0.4695 mL | 1.1738 mL | |
| 100 mM | 0.0376 mL | 0.1878 mL | 0.3756 mL | 0.9390 mL |
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