7292-81-1
Chemical Structure
(RS)-4CPG
Synonym(s): (RS)-4-Carboxyphenylglycine
- CAS No.: 7292-81-1
- Formula:C9H9NO4
- Molecular Weight:195.17
IUPAC Name: 4-(amino(carboxy)methyl)benzoic acid
InChIKey: VTMJKPGFERYGJF-UHFFFAOYSA-N
SMILES: O=C(O)C(N)C1=CC=C(C(O)=O)C=C1
Biological Activity: (RS)-4CPG ((RS)-4-Carboxyphenylglycine) is a type I metabotropic glutamate receptor antagonist with activity in blocking LTP induction. In mice lacking IP3R1, (RS)-4CPG (500μM) nearly blocked long-term potentiation (LTP) induced by type I metabotropic glutamate receptor activation, with LTP of 117.6±1.7% (n = 8) in IP3R1(-/-) mice and 116.9±1.8% (n = 5) in IP3R1(+/+) mice.
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(RS)-4CPG | (RS)-4CPG ((RS)-4-Carboxyphenylglycine) is a type I metabotropic glutamate receptor antagonist with activity in blocking LTP induction. In mice lacking IP3R1, (RS)-4CPG (500μM) nearly blocked long-term potentiation (LTP) induced by type I metabotropic glutamate receptor activation, with LTP of 117.6±1.7% (n = 8) in IP3R1(-/-) mice and 116.9±1.8% (n = 5) in IP3R1(+/+) mice. | |||||||||||||||||||||
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