(E)-PHCCC
(E)-PHCCC is a positive allosteric modulator (PAM) for mGluR4, that enhances the activity of the receptor's endogenous ligand (glutamate), and exhibits activity in the calcium mobilization assay in CHO cells with an EC50 of 3.2 μM.
For research use only. We do not sell to patients.
- CAS No.: 177610-87-6
- Formula: C17H14N2O3
- Molecular Weight:294.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
3 μM
Compound: 4b
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Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
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10.1016/0960-894X(96)00104-7 |
Chemical Information
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CAS No. 177610-87-6
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Molecular Weight 294.30
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Formula C17H14N2O3
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SMILES
O=C(C12C(/C(C3=CC=CC=C3O2)=N\O)([H])C1)NC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E)-PHCCC Related Classifications
HY-111332 Related Classifications
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