Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

  • ACS Chem Neurosci. 2010 Jun 16;1(6):411-419. doi: 10.1021/cn9000318.
Richard Williams  1 ,  Ya Zhou ,  Colleen M Niswender ,  Qingwei Luo ,  P Jeffrey Conn ,  Craig W Lindsley ,  Corey R Hopkins
Affiliations
  • 1. Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
PMID: 20582156 DOI: 10.1021/cn9000318
Abstract

This Letter describes a detailed SAR analysis of the mGluR4 positive allosteric modulator, PHCCC. We have now developed compounds with improved potency and efficacy; in addition, compounds are presented that show selectivity for mGluR4 versus the other mGluR subtypes.

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