2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. MNI137

MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization.

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MNI137 Chemical Structure

MNI137 Chemical Structure

CAS No. : 946619-21-2

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5 mg USD 650 In-stock
10 mg USD 970 In-stock
50 mg USD 1940 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization[1].

Molecular Weight

341.16

Formula

C15H9BrN4O
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

N#CC1=NC=CC(C2=NC3=CC=C(Br)C=C3NC(C2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (244.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9312 mL 14.6559 mL 29.3118 mL
5 mM 0.5862 mL 2.9312 mL 5.8624 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9312 mL 14.6559 mL 29.3118 mL 73.2794 mL
5 mM 0.5862 mL 2.9312 mL 5.8624 mL 14.6559 mL
10 mM 0.2931 mL 1.4656 mL 2.9312 mL 7.3279 mL
15 mM 0.1954 mL 0.9771 mL 1.9541 mL 4.8853 mL
20 mM 0.1466 mL 0.7328 mL 1.4656 mL 3.6640 mL
25 mM 0.1172 mL 0.5862 mL 1.1725 mL 2.9312 mL
30 mM 0.0977 mL 0.4885 mL 0.9771 mL 2.4426 mL
40 mM 0.0733 mL 0.3664 mL 0.7328 mL 1.8320 mL
50 mM 0.0586 mL 0.2931 mL 0.5862 mL 1.4656 mL
60 mM 0.0489 mL 0.2443 mL 0.4885 mL 1.2213 mL
80 mM 0.0366 mL 0.1832 mL 0.3664 mL 0.9160 mL
100 mM 0.0293 mL 0.1466 mL 0.2931 mL 0.7328 mL
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MNI137 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MNI137946619-21-2MNI 137MNI-137mGluRMetabotropic glutamate receptorsselectivemGluRsglutamate-inducedcalcium mobilizationInhibitorinhibitorinhibit

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